ID   A0A1I2CIT2_9BURK        Unreviewed;       699 AA.
AC   A0A1I2CIT2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SFE67630.1};
GN   ORFNames=SAMN04489711_10492 {ECO:0000313|EMBL:SFE67630.1};
OS   Paracidovorax wautersii.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Paracidovorax.
OX   NCBI_TaxID=1177982 {ECO:0000313|EMBL:SFE67630.1, ECO:0000313|Proteomes:UP000199119};
RN   [1] {ECO:0000313|EMBL:SFE67630.1, ECO:0000313|Proteomes:UP000199119}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27981 {ECO:0000313|EMBL:SFE67630.1,
RC   ECO:0000313|Proteomes:UP000199119};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; FONX01000004; SFE67630.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2CIT2; -.
DR   STRING; 1177982.SAMN04489711_10492; -.
DR   OrthoDB; 5287258at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199119; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT   DOMAIN          299..475
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          480..572
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          608..696
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   699 AA;  75100 MW;  05A0EE86896C088E CRC64;
     MTAAYEVHGD IAVITLNNPP VNGLGHATRK GITDGIERAN ADAAVKAIVI TGAGGAFSGG
     ADIKEFGTDK ALQEPNLLSV ISTVEASDKP VVAAIHTVCM GGGLELALGC HYRIAAPGCN
     VALPEVKLGL VPGAGGTQRL PRVLGVEAAL NIIVSGEPVK SELIGSFPGQ KLFDKMAASA
     ESLAEEALAF ARSVADARPL PLVRNLPCKH PQGDAYFQFA RNMVKGMAKN LPAPAKCVDA
     VEAATKRKFA DGMAYEREIF INLMWTPESR ALRHIFFSER AASKIPDVPS DTPQRAVKTV
     GVIGAGTMGG GIAMNFLNAG IPVTILETKQ EALDRGVATI KKNYEAQVKK GKLKEDKYQQ
     RMGLLKTTLS YGDLKDADLI IEAVFEEMGV KEAVFKQLDA VAKPGAILAS NTSTLDVDQI
     AAFTQRPQDV VGMHFFSPAN VMRLLEVVRG KATAKDVLAT VMSIAKKIRK TAVVSGVCDG
     FIGNRMIERY SQQAGFLLDE GATPQQVDRA IEKFGFAMGP FRMGDLAGND IGWAIRKRRA
     VERPDMKYSR TADKLCELGR FGQKTGAGWY DYAPGKRDAI PSELVNKMVE DHRKELGVTP
     RKISDEEIVQ RLVFSLVNEG AKILEEGIAS KSGDIDMVYL TGYGFPIHRG GPMHYASELG
     LFNVEQAMKR FAKNPLDDAS AWEPAPLLSR LAAEGKAFA
//