ID   A0A1I2EJP6_9BACT        Unreviewed;       211 AA.
AC   A0A1I2EJP6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Deoxyadenosine/deoxycytidine kinase {ECO:0000313|EMBL:SFE92736.1};
GN   ORFNames=SAMN05216167_12240 {ECO:0000313|EMBL:SFE92736.1};
OS   Spirosoma endophyticum.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cytophagaceae; Spirosoma.
OX   NCBI_TaxID=662367 {ECO:0000313|EMBL:SFE92736.1, ECO:0000313|Proteomes:UP000198598};
RN   [1] {ECO:0000313|EMBL:SFE92736.1, ECO:0000313|Proteomes:UP000198598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26130 {ECO:0000313|EMBL:SFE92736.1,
RC   ECO:0000313|Proteomes:UP000198598};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOLQ01000022; SFE92736.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2EJP6; -.
DR   STRING; 662367.SAMN05216167_12240; -.
DR   OrthoDB; 9776634at2; -.
DR   Proteomes; UP000198598; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01673; dNK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Kinase {ECO:0000313|EMBL:SFE92736.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198598};
KW   Transferase {ECO:0000313|EMBL:SFE92736.1}.
FT   DOMAIN          3..208
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
FT   ACT_SITE        87
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT   BINDING         7..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT   BINDING         31
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         43
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         54
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         88
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         93
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         154
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
SQ   SEQUENCE   211 AA;  24560 MW;  926E2020130BDCF4 CRC64;
     MHIAITGNIG AGKTTLAEQL AAHYGWEVLY EAVEGNPYLA DFYDDMPRWS FNLQIYFLNS
     RFAQVKKIMD IQQANRVASH PKTVVQDRTI YEDAAIFARN LYQNASMTER DYDTYQHLFA
     NMMSLVRPPD LMIYLRASLP KLREQIQKRG RSYEQRISDE YLTSLNQLYE EFVASYQFGP
     VLVLDVNALD YANKPTDFKY VLDQIDAQLK I
//