UniProt: A0A1I2EM77

Database: UniProt
Entry: A0A1I2EM77_9ACTN

LinkDB:  A0A1I2EM77_9ACTN 
Original site:  A0A1I2EM77_9ACTN

All links

Ontology (4)   
   GO (4)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (39)   
   InterPro (21)   
   Pfam (9)   
   PROSITE (3)   
   SMART (6)   
All databases (44)   

Download RDF

ID   A0A1I2EM77_9ACTN        Unreviewed;      2100 AA.
AC   A0A1I2EM77;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Thioester reductase domain-containing protein {ECO:0000313|EMBL:SFE93340.1};
GN   ORFNames=SAMN05421541_104539 {ECO:0000313|EMBL:SFE93340.1};
OS   Actinoplanes philippinensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=35752 {ECO:0000313|EMBL:SFE93340.1, ECO:0000313|Proteomes:UP000199645};
RN   [1] {ECO:0000313|EMBL:SFE93340.1, ECO:0000313|Proteomes:UP000199645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43019 {ECO:0000313|EMBL:SFE93340.1,
RC   ECO:0000313|Proteomes:UP000199645};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FONV01000004; SFE93340.1; -; Genomic_DNA.
DR   STRING; 35752.SAMN05421541_104539; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000199645; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   CDD; cd05235; SDR_e1; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01746; Thioester-redct; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199645};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          33..456
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1611..1689
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2100 AA;  219912 MW;  765B5CE2610E65AF CRC64;
     MSNEEKLVDY LKWVTADLQQ ARARIAELED PQRDPVAVVG MSCRFPGAQN PDELWRVAVE
     ERDEITPFPT DRGWDLDALY DPDPAKPGHI YIREAGFVAT AGLFDAGFFG ISPREALAMD
     PQQRLLLESA WEALEHAGID PETLTGSRTG VFAGLVEQSY LDLDPPPEFE GYQMTSKLSS
     MASGRISYAL GLQGPAVSID TACSSALVAV HLAAQSLRRG ESTLALAGAA YVAAHPGGYL
     DGSRQRGLAP DGRCKPFSAA ADGIGWSEGA GVIVLERLAD ARRNGHRVLA VVRGSAVNSD
     GASNGLTAPN GLAQERVIRQ ALADAGLTTA DVDAVEAHGT GTRLGDPIEA GALLATYGTG
     RPEGRPVLVG SLKSNVGHAQ AAAGIGGIVK MVQALRHGVL PRTLHLDEPS PFVDWSAGDV
     ELLTTTRPWP AVDRPRRGAV SAFGASGTNA HLLLEQAPAE EPSDEEPVAA GPLPWAVSAK
     TPAALRGQAA RLAAHVRSLP AGDRPGVLRD LAYSLATTRT AFPHRAVVVA TDRDAVLAGL
     DALATGATAE HLVTGTATDR GRTVFVFPGQ GSQWPGMATA LLASSDVFAG RIAECVKAFE
     PHLDWSLDDV LRGLPGAPSL DRVEVVQPAL FAVHVALAAM WEAAGVRPDA VTGHSQGEIA
     AAVVAGAISL ADGARVIAVR SRLARRLEGL GGMAAIGLPR ADVERRLARF DGRLTLAVEN
     GPASVLVAGE RADLDELVAE CAAAGARTKR FPADFPSHSP QVAVVEREML DALREVRPRA
     AAVPLYSTVT GGRLDTTGMD ASYWYANMRR PVEFAATVRA LADAGHDTFI EVSAHPVLLA
     SLRDNLGAEG LAGGTLRRDT DAVQTFQLAV AHVATHGVAT DREHPFAGLN PRVTPLPTYA
     FEHTRYWHLG SGRSGDAGGL GLRDTAHPLL GAAVSLAGGD ETVFTTRLPI PGTPAVTGAT
     VLEMVSRAGD ETGCTTVREL RTVIPLTLPA RGGLQVQVRV GAPGDRGLRP VTVHARPAHS
     DGPWTRHADG TLGVAIAAAP EPITNWPSES GPAGGSPHRY TEVTLPESQA GDAGRYVLHP
     ALLDRLLATA PGDGPVRAWR DWQVHATGAT TVRARITPAG DGFSAVLADR AGRIVATLGA
     VERGPDDPVR EPAPDAMLAV RWVPAEVTGP HPDHDWAVLV AADPDHPDRL RAALDRAAAA
     TAVRYDCGGA HTDSASAGRA HVHTRRVLTL VRAWLADDRL TGIPLVITTG GAVPAGGPVT
     DPAAAAVWGQ IRAAQSENPG RFLLADIDGD GDPYPMLSRL VASGVAQAAV RSGVLLIPRL
     RRIGATPSVP PWAPGGTVLV TGGTGALGAL FAKHLVAAHG VADLVLTSRR GPAAPGADRL
     AAELAGLGAR VRIVACDTGD RDALRRVLDD IPAQHPLTGI VHAAGVIDDG LITSATADRL
     DAVLRPKADG AWHLHELTRD LPLAGFVLFS SLAGVIGGAG QSSYAAANTF LDALATHRRG
     LGLPATSIAW GVWAISGAGG ELSAADIDRI ARAGYPPIAT GAGTALFDAA LACGEPGVVV
     APLDPEALRA RPDQVPPMLD TVLRLIRREA AGNDAARAGL IEELAALPAG ERRDRLVDLV
     RAEAAAVLGH ADPGGIPVDQ RLSDLGFDSL TGVEFRNRLG MLAGLRLPPT FVFDHPTLLD
     AAGHLAGRLG GDEHGRPGGD GYDRPAGPDF AADLTLDDDI RPADEVHRFA ADPREVLLTG
     ATGFLGAYLL RDLMRQTRAR VHCLIRGAGP DEARQRLLDN LDWYGLTGQI DPDRLIVVPG
     DLAAPRLGLT GDDYDTLART VDAVYHAGAA VNWVQPYATV RAANVGGTAE ILRLAARFRT
     VPVHYVSTLG VYVGRDTAGA GLRVGDPAGP GERLPTGYTQ SKWVAEQIID IARGRGLPVS
     VYRIDLIAGD SGSGACQSRD YVWLTLKGMV QSSAVPEPVP VRFRLMPVDY TSAAILHISR
     REQTAGGTFH VAGHGDIALE EMIDELRRTG YPLAELPTGD WRAAITGDPA NALLPLLDAF
     DVMAAAPDRF YPPVDDRETV AALAGSGISC PPVTREFFRR HVEFFIDRGW FPAPADGGAA
//

DBGET integrated database retrieval system