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Entry: A0A1I2EQW2_9BACT
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ID   A0A1I2EQW2_9BACT        Unreviewed;       239 AA.
AC   A0A1I2EQW2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   RecName: Full=4-hydroxy-tetrahydrodipicolinate reductase {ECO:0000256|SAAS:SAAS01081423};
DE            EC=1.17.1.8 {ECO:0000256|SAAS:SAAS01081445};
GN   ORFNames=SAMN05444380_12413 {ECO:0000313|EMBL:SFE95504.1};
OS   Thermophagus xiamenensis.
OC   Bacteria; Bacteroidetes; Bacteroidia; Marinilabiliales;
OC   Marinilabiliaceae; Thermophagus.
OX   NCBI_TaxID=385682 {ECO:0000313|EMBL:SFE95504.1, ECO:0000313|Proteomes:UP000181976};
RN   [1] {ECO:0000313|EMBL:SFE95504.1, ECO:0000313|Proteomes:UP000181976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19012 {ECO:0000313|EMBL:SFE95504.1,
RC   ECO:0000313|Proteomes:UP000181976};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of 4-hydroxy-
CC       tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
CC       {ECO:0000256|SAAS:SAAS01081415}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) =
CC         (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH;
CC         Xref=Rhea:RHEA:35323, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16845, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:67139; EC=1.17.1.8;
CC         Evidence={ECO:0000256|SAAS:SAAS01117954};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) =
CC         (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:35331, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16845, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:67139; EC=1.17.1.8;
CC         Evidence={ECO:0000256|SAAS:SAAS01117970};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.
CC       {ECO:0000256|SAAS:SAAS01081412}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS01081435}.
CC   -!- SIMILARITY: Belongs to the DapB family.
CC       {ECO:0000256|SAAS:SAAS01081404}.
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DR   EMBL; FONA01000024; SFE95504.1; -; Genomic_DNA.
DR   RefSeq; WP_010527455.1; NZ_FONA01000024.1.
DR   STRING; 385682.AFSL01000046_gene543; -.
DR   OrthoDB; 803114at2; -.
DR   BioCyc; GCF_900112795:G1FNL-2225-MONOMER; -.
DR   UniPathway; UPA00034; UER00018.
DR   Proteomes; UP000181976; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008839; F:4-hydroxy-tetrahydrodipicolinate reductase; IEA:UniProtKB-EC.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR022663; DapB_C.
DR   InterPro; IPR000846; DapB_N.
DR   InterPro; IPR022664; DapB_N_CS.
DR   InterPro; IPR023940; DHDPR_bac.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR20836; PTHR20836; 1.
DR   Pfam; PF05173; DapB_C; 1.
DR   Pfam; PF01113; DapB_N; 1.
DR   PIRSF; PIRSF000161; DHPR; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00036; dapB; 1.
DR   PROSITE; PS01298; DAPB; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|SAAS:SAAS01081390};
KW   Complete proteome {ECO:0000313|Proteomes:UP000181976};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS01081408};
KW   Diaminopimelate biosynthesis {ECO:0000256|SAAS:SAAS01081418};
KW   Lysine biosynthesis {ECO:0000256|SAAS:SAAS01081406};
KW   NAD {ECO:0000256|SAAS:SAAS01081420};
KW   NADP {ECO:0000256|SAAS:SAAS00333002};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00333034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000181976}.
FT   DOMAIN        1    104       DapB_N. {ECO:0000259|Pfam:PF01113}.
FT   DOMAIN      107    237       DapB_C. {ECO:0000259|Pfam:PF05173}.
SQ   SEQUENCE   239 AA;  26740 MW;  419921D51A942F1C CRC64;
     MKIALIGYGK MGKEIEKVAQ SRGHEIVARI DPAATGESFD DGGFQSADVA IEFTAPRVAF
     SNYLKCFEYN KPVVSGTTGW LDKLPEIKKA CSNNQQTFFY ASNFSIGVNI LFELNRRLAQ
     IMNDRDEYDV EITEVHHTQK LDAPSGTAIS LAQDIIDNID RKKDWKLDKT DTDTDLLIKA
     KREGDIPGIH TVKYESEIDE ITIHHSAKSR KGFALGAVLA AEFTINNKGF LTMKDMLKF
//
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