ID A0A1I2GUE6_9GAMM Unreviewed; 227 AA.
AC A0A1I2GUE6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=SAMN02799615_02748 {ECO:0000313|EMBL:SFF21072.1};
OS Dyella marensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Rhodanobacteraceae; Dyella.
OX NCBI_TaxID=500610 {ECO:0000313|EMBL:SFF21072.1, ECO:0000313|Proteomes:UP000199477};
RN [1] {ECO:0000313|EMBL:SFF21072.1, ECO:0000313|Proteomes:UP000199477}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNC178MFTsu3.1 {ECO:0000313|EMBL:SFF21072.1,
RC ECO:0000313|Proteomes:UP000199477};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; FONH01000010; SFF21072.1; -; Genomic_DNA.
DR RefSeq; WP_026633883.1; NZ_FONH01000010.1.
DR AlphaFoldDB; A0A1I2GUE6; -.
DR STRING; 500610.SAMN02799615_02748; -.
DR Proteomes; UP000199477; Unassembled WGS sequence.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:SFF21072.1};
KW Protease {ECO:0000313|EMBL:SFF21072.1};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 25..220
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
FT REGION 44..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 24315 MW; 144ADA53563665CC CRC64;
MKILMVLTSH DQLGDTGRKT GFWLEEFAAP YYAFKDAGAQ IVLASPKGGQ PPLDPKSDDP
DAQTDATRRF RADARATDAL AHTLPLADAA RAQYDAVFYP GGHGPLWDLA EDKTSAELIE
RTYAAGKPVG AVCHGPAVFR HTRIKGEPLV RGKRVTGFTN GEEAAVGLTD VVPFLVEDML
KAHGAEYSKK ADFHPYAVTD GNLVTGQNPA SSVDAAKAVL ALLRNED
//
