ID A0A1I2HIY1_9ACTN Unreviewed; 181 AA.
AC A0A1I2HIY1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Diadenosine tetraphosphate (Ap4A) hydrolase {ECO:0000313|EMBL:SFF29250.1};
GN ORFNames=SAMN05216574_11129 {ECO:0000313|EMBL:SFF29250.1};
OS Blastococcus sp. DSM 46838.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Blastococcus.
OX NCBI_TaxID=1798228 {ECO:0000313|EMBL:SFF29250.1, ECO:0000313|Proteomes:UP000198589};
RN [1] {ECO:0000313|Proteomes:UP000198589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46838 {ECO:0000313|Proteomes:UP000198589};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOND01000011; SFF29250.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2HIY1; -.
DR STRING; 1798228.SAMN05216574_11129; -.
DR OrthoDB; 9784774at2; -.
DR Proteomes; UP000198589; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:SFF29250.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198589}.
FT DOMAIN 37..146
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 131..135
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 133
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 63
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 135
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 181 AA; 19484 MW; CD546D3A3CA95964 CRC64;
MGMSDDGPGT AFEHLWTPYR MAYIRGEGKP TGAHDCPFCV IPTMDDEQGL VVARGATVFA
VLNLYPYNAG HLMLVPYRHV PDYTDLTPAE VAELGTFTQT AMRTVRAVSG AHGFNIGMNQ
GSVAGAGIAD HLHQHAVPRW GGDTNFMPVI GLTRVLPQVL RETRALLAEA WADQAVPVGE
A
//
