ID A0A1I2HPN5_9GAMM Unreviewed; 588 AA.
AC A0A1I2HPN5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN04488120_10256 {ECO:0000313|EMBL:SFF30686.1};
OS Fontimonas thermophila.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Nevskiales; Nevskiaceae;
OC Fontimonas.
OX NCBI_TaxID=1076937 {ECO:0000313|EMBL:SFF30686.1, ECO:0000313|Proteomes:UP000199771};
RN [1] {ECO:0000313|EMBL:SFF30686.1, ECO:0000313|Proteomes:UP000199771}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23609 {ECO:0000313|EMBL:SFF30686.1,
RC ECO:0000313|Proteomes:UP000199771};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FOOC01000002; SFF30686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2HPN5; -.
DR STRING; 1076937.SAMN04488120_10256; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000199771; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000199771}.
FT DOMAIN 211..329
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 398..544
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 588 AA; 64858 MW; 6FDCF6B7DCDB47CC CRC64;
MIRILPDQLI NQIAAGEVVE RPAAVVKELI ENSLDAGARR IDIELEQGGI GLIRVRDDGA
GIPKNELPLA FQRHATSKIA SLGDLERIAS LGFRGEALPS ILSVSRMRLT SRTAQDAHAW
MLGGEGKLDS AAPVPAAHPP GTGVEVRDLF FNTPARRKFL KTESTEFRYA QQAVERIALS
HFEVAFSLKH NQRRVLDLAA ADREATRQAR IEAICGGEFV AQSQQLDASR LGMRLYGWIG
LPSFARSQPD LQFFYVNGRF VRDRLAAFAL RRAFADVMHS THHPAYVLYL EIDPTLVDVN
VHPQKTEVRF REAARVHDLL FGAVHQALRG LRPDPVRHHR VVLDAAVPAP PQPALPYALD
VRVKPEIPHL AEPSAAYVEP VVSPTPAGMA DEPPLGHALA QLHGVYILAQ NRHGLVLVDA
HAAHERVLYE RMKRQLDGGG IPAQALLIPQ TLTLHEDEAD ALEARRAALY RCGIEIDRTG
PTTVCVRAVP PLLGGDDVAG LIRGLVRDDE RHQVAQHFNE VIEAQYRVLA DVACKAAIKA
NRRLTLAEMD ALLRDMEATA LSGQCNHGRP TWVQVGLREL DRLFLRGR
//
