ID   A0A1I2K6Y9_9BACT        Unreviewed;       323 AA.
AC   A0A1I2K6Y9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Isopenicillin N synthase {ECO:0000313|EMBL:SFF60656.1};
GN   ORFNames=SAMN04488541_10796 {ECO:0000313|EMBL:SFF60656.1};
OS   Thermoflexibacter ruber.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Thermoflexibacteraceae;
OC   Thermoflexibacter.
OX   NCBI_TaxID=1003 {ECO:0000313|EMBL:SFF60656.1, ECO:0000313|Proteomes:UP000199513};
RN   [1] {ECO:0000313|EMBL:SFF60656.1, ECO:0000313|Proteomes:UP000199513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GEY, DSM 9560 {ECO:0000313|Proteomes:UP000199513};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC       family. {ECO:0000256|RuleBase:RU003682}.
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DR   EMBL; FONY01000079; SFF60656.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2K6Y9; -.
DR   STRING; 1003.SAMN04488541_10796; -.
DR   OrthoDB; 21825at2; -.
DR   Proteomes; UP000199513; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026992; DIOX_N.
DR   InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR   InterPro; IPR027443; IPNS-like_sf.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   PANTHER; PTHR47990; 2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED; 1.
DR   PANTHER; PTHR47990:SF27; FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   Pfam; PF14226; DIOX_N; 1.
DR   PRINTS; PR00682; IPNSYNTHASE.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|RuleBase:RU003682};
KW   Metal-binding {ECO:0000256|RuleBase:RU003682};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003682};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199513}.
FT   DOMAIN          173..282
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51471"
SQ   SEQUENCE   323 AA;  36577 MW;  C9E0FE36A5AFAB6A CRC64;
     MKEILYDEIP SLDLADFTSN DPQRKANFVQ KLGEAWQNIG FVAIKNHGLS DELTERLYNN
     VKNFFSLPDA TKQKYENPTL AGQRGYISKN KEHAKGRSTP DLKEFYHIGQ TVPENVKLTE
     TYPDNIFPNE VPDFEPSALE AYRTLENAGI QILRAAALFL GLEENYFDEK VKYGNSILRA
     IHYYPIEQPE LLPPDAVRAA AHGDINLITL LMGASAEGLQ VLRRDNKWIP ITALPEQIVV
     NVGDMLERLT NNVLKSTIHR VVNPPAEKLK TPRFSIPFFM HPRSEMSLAC LPNCITPDNP
     KQYEDITAGE FLNQRLAEIG LKK
//