ID A0A1I2L0U2_9CLOT Unreviewed; 512 AA.
AC A0A1I2L0U2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Citrate lyase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE Short=Citrase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE EC=2.8.3.10 {ECO:0000256|PIRNR:PIRNR009451};
DE EC=4.1.3.6 {ECO:0000256|PIRNR:PIRNR009451};
DE AltName: Full=Citrate (pro-3S)-lyase alpha chain {ECO:0000256|PIRNR:PIRNR009451};
DE AltName: Full=Citrate CoA-transferase subunit {ECO:0000256|PIRNR:PIRNR009451};
GN Name=citF {ECO:0000313|EMBL:PWL51495.1};
GN ORFNames=DBY38_14760 {ECO:0000313|EMBL:PWL51495.1}, SAMN04487885_10864
GN {ECO:0000313|EMBL:SFF72825.1};
OS Clostridium cadaveris.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1529 {ECO:0000313|EMBL:SFF72825.1, ECO:0000313|Proteomes:UP000182135};
RN [1] {ECO:0000313|EMBL:SFF72825.1, ECO:0000313|Proteomes:UP000182135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-G419 {ECO:0000313|EMBL:SFF72825.1,
RC ECO:0000313|Proteomes:UP000182135};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PWL51495.1, ECO:0000313|Proteomes:UP000246114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIM:MAG 903 {ECO:0000313|EMBL:PWL51495.1};
RA Jeraldo P., Boardman L., White B.A., Nelson H., Goldenfeld N., Chia N.;
RT "The uncultured portion of the human microbiome is neutrally assembled.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + citrate = (3S)-citryl-CoA + acetate;
CC Xref=Rhea:RHEA:19405, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57321; EC=2.8.3.10;
CC Evidence={ECO:0000256|PIRNR:PIRNR009451};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = acetate + oxaloacetate; Xref=Rhea:RHEA:10760,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089; EC=4.1.3.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR009451};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR009451}.
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DR EMBL; QAMZ01000056; PWL51495.1; -; Genomic_DNA.
DR EMBL; FOOE01000008; SFF72825.1; -; Genomic_DNA.
DR RefSeq; WP_027637798.1; NZ_OBJM01000011.1.
DR AlphaFoldDB; A0A1I2L0U2; -.
DR STRING; 1529.SAMN04487885_10864; -.
DR eggNOG; COG3051; Bacteria.
DR OrthoDB; 9767643at2; -.
DR Proteomes; UP000182135; Unassembled WGS sequence.
DR Proteomes; UP000246114; Unassembled WGS sequence.
DR GO; GO:0009346; C:ATP-independent citrate lyase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008815; F:citrate (pro-3S)-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008814; F:citrate CoA-transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 2.
DR InterPro; IPR006472; Citrate_lyase_asu.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01584; citF; 1.
DR PANTHER; PTHR40596; CITRATE LYASE ALPHA CHAIN; 1.
DR PANTHER; PTHR40596:SF1; CITRATE LYASE ALPHA CHAIN; 1.
DR Pfam; PF04223; CitF; 1.
DR PIRSF; PIRSF009451; Citrt_lyas_alpha; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR009451};
KW Lyase {ECO:0000256|PIRNR:PIRNR009451, ECO:0000313|EMBL:SFF72825.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000182135};
KW Transferase {ECO:0000256|PIRNR:PIRNR009451, ECO:0000313|EMBL:SFF72825.1}.
SQ SEQUENCE 512 AA; 54319 MW; 8130AB3A4589CC67 CRC64;
MKNAVGRELP SYIEGYGEVV PFQGAENNST VKPKTTVKGS AVGPKDVKIL SSISEAIDKA
EIKDGMTISF HHHLRNGDYV LNMVMEEIAK RGIKDLTIAA SSIFPCHEPL VEHIRNGVVT
KVIAAYMSGP VAAAISRGEL KYPAVMQTHG GRGRAIENGE VHIDVAFVAA PSSDDYGNIN
GLQGPAACGS LGYAVADCLY GDKVIAITDH LVAYPNCPIE IDETNIDYVV KVDSIGNPAG
IVSGTTKVTK DPVGLKIAQM TAKLMKASGL VKDGLSFQTG AGGTSLAVAQ ELKDIMKNEG
IKGSFASGGI TGYIVDMYEE GLFQSLFDVQ CFDLKAVESL RSNKAHQSMS ASMYGNPHNK
GAVVNKLDIV ILGATEIDTD FNVNVTTGSD GVIMGGSGGH SDTAAGAKLT IIVSNLVKAR
LPIIKDKVTT VTTPGESIDV LVTERGIAIN PKHADLIERL KKTNLPIMTI EELKEVAEKL
TGKPKEIESD DKIVAVIEYR DGTVIDVVKK VK
//
