ID A0A1I2L3J9_9MICO Unreviewed; 345 AA.
AC A0A1I2L3J9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Hemolysin, contains CBS domains {ECO:0000313|EMBL:SFF73118.1};
GN ORFNames=SAMN05216329_2420 {ECO:0000313|EMBL:SFF73118.1};
OS Curtobacterium sp. YR515.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Curtobacterium.
OX NCBI_TaxID=1855316 {ECO:0000313|EMBL:SFF73118.1, ECO:0000313|Proteomes:UP000199282};
RN [1] {ECO:0000313|EMBL:SFF73118.1, ECO:0000313|Proteomes:UP000199282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR515 {ECO:0000313|EMBL:SFF73118.1,
RC ECO:0000313|Proteomes:UP000199282};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOOD01000004; SFF73118.1; -; Genomic_DNA.
DR RefSeq; WP_070416367.1; NZ_FOOD01000004.1.
DR AlphaFoldDB; A0A1I2L3J9; -.
DR OrthoDB; 110231at2; -.
DR Proteomes; UP000199282; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR43099:SF5; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..203
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 220..279
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 284..342
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 345 AA; 38391 MW; CDFBA7C2E70450C7 CRC64;
MSSDWWGIFW LVVLLMGNAY FVAAEFAVIS ARRSQIEPRA EEGSRAAQMT LWAMEHATRM
LATTQLGITV CSLLILNVSE PAIHHLLEVP LHLTGWSVEV IGVVAFVFTL LLVSFLHVVF
GEMVPKNISF SMPDRAALLL VPTLWYIGHG LHWVVVGLNE VANAVLRLFR VEPKDEAVSA
FTVEEVQTIV EQSRREGTLT DDGKLALAFE FTEKKVKDVA VPMAELVTLP EDATPGDVER
AVAQRGFSRY VLVAEDGSPT GYVHVKDVID LRPDEYDDPV PPKRIRQLIS LYTEMDLEDA
LATMRAAGRH VARAFDAEGR TLGVLFLEDI LEELVGTVED ATRRR
//
