ID   A0A1I2LAA4_9ACTN        Unreviewed;       640 AA.
AC   A0A1I2LAA4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=SAMN05421541_12013 {ECO:0000313|EMBL:SFF74121.1};
OS   Actinoplanes philippinensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=35752 {ECO:0000313|EMBL:SFF74121.1, ECO:0000313|Proteomes:UP000199645};
RN   [1] {ECO:0000313|EMBL:SFF74121.1, ECO:0000313|Proteomes:UP000199645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43019 {ECO:0000313|EMBL:SFF74121.1,
RC   ECO:0000313|Proteomes:UP000199645};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; FONV01000020; SFF74121.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2LAA4; -.
DR   STRING; 35752.SAMN05421541_12013; -.
DR   OrthoDB; 3272969at2; -.
DR   Proteomes; UP000199645; Unassembled WGS sequence.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00075; HATPase; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR   PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00989; PAS; 2.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199645}.
FT   DOMAIN          172..243
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          296..365
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          437..640
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   640 AA;  69057 MW;  730BB6E6FD440EEC CRC64;
     MDTERRIAQA DRLAAVASTG LLTLPPAPGL DRLTRLASRL LGVPTTLVSL VTDERQVFAS
     QLGLPQPWAD AGQTPLSHSF CQYVVDDDAP LVVTDARDDE RLRDNRAIDE IGVIAYAGMP
     IRLDGQTLGA FCAIDGQPRK WTAAELETLE DLAAAVDSEI ALIKAADDAQ QAAATMRAVL
     EASHDAYVST DARGLVVDWN QAAEALFGWT RDEAIGALAT ELIIPAEHRD RYNADIDRVR
     AGGRSELAGR RMEMPVRHRD GRYFPVEYTV QVTDVGSPVY HAFLHDISAR RAAQRQLRRQ
     AELIDAAPAA IIVRGDDGTI RFWNNGAEQM YGWPAAAVAG QDIHQLLHTG FPDGLAEVRE
     ALETAGTWEG ELTHRCADGH TITVLSRHAR RPAPDGGTEV IETNADITGR LLAQRELQQR
     NRQLEQANLL KLDLMGMLSH DIGTPLAAIT GYSELLGEEP LPEFVLGLIG RIRKSAHRID
     ELRHNVLAMC SLDSGTLTAC RQPVLLGPAL REAVEALEAD VPVDCPDGLR VLVNPAHLTQ
     IVVNFITNAA KYGGGATGIT VRAGDATVTV SVHDEGPGVP AGLRSRLFDR YTRAHETGGA
     KGHGLGLHIV ASLAGANHGT VTHRDNQPRG SVFELTLESA
//