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Database: UniProt
Entry: A0A1I2M426_9BACL
LinkDB: A0A1I2M426_9BACL
Original site: A0A1I2M426_9BACL 
ID   A0A1I2M426_9BACL        Unreviewed;       437 AA.
AC   A0A1I2M426;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN04488025_106103 {ECO:0000313|EMBL:SFF84196.1};
OS   Planifilum fulgidum.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Thermoactinomycetaceae;
OC   Planifilum.
OX   NCBI_TaxID=201973 {ECO:0000313|EMBL:SFF84196.1, ECO:0000313|Proteomes:UP000198661};
RN   [1] {ECO:0000313|EMBL:SFF84196.1, ECO:0000313|Proteomes:UP000198661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44945 {ECO:0000313|EMBL:SFF84196.1,
RC   ECO:0000313|Proteomes:UP000198661};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FOOK01000006; SFF84196.1; -; Genomic_DNA.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000198661; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198661};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198661};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       10    128       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      136    315       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
SQ   SEQUENCE   437 AA;  48007 MW;  F8E758FF55BCB295 CRC64;
     MDRIDVALLG LGTVGTGVYK MLQSNQDVIA RRTGLLFEVK HILVRDPNKK RKVDGVQHLL
     TTRFEEIMAT GVDVVMEAMG GVEPARTYIE RAIRTRCHVV TANKELIAKH GAELEKLARE
     HGVQLLYEAS VGGGIPVLGT LQHFLKANRI MRVSGILNGT TNFILTQMGE HQRPFEEVLA
     EAQRRGYAEA DPTADVEGLD AAHKLAILSR LAFGAVVSVD EIARRGITDI SPEELELAHR
     LGYKIKLLAK AEQFGEEGPV ALQVGPTLVP LSHPLAGING VYNAIHVEAD TVQDVTLVGQ
     GAGEQPTASA MVEDLCNLFR LPLPRPLPYR RPLVLPVWEE GGARFAFIET KDRLGSDISH
     QVKERLKRFG TSAVDVAWLP GAERGALALI LRRWDPSLEE KLTEELGLEA ERVVFRPLLG
     MPEPVGEERE EKISSAQ
//
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