ID A0A1I2MJG0_9ACTN Unreviewed; 528 AA.
AC A0A1I2MJG0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=succinate-semialdehyde dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00039122};
DE EC=1.2.1.79 {ECO:0000256|ARBA:ARBA00039122};
GN ORFNames=SAMN05216251_13723 {ECO:0000313|EMBL:SFF91655.1};
OS Actinacidiphila alni.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Actinacidiphila.
OX NCBI_TaxID=380248 {ECO:0000313|EMBL:SFF91655.1, ECO:0000313|Proteomes:UP000199323};
RN [1] {ECO:0000313|EMBL:SFF91655.1, ECO:0000313|Proteomes:UP000199323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3510 {ECO:0000313|EMBL:SFF91655.1,
RC ECO:0000313|Proteomes:UP000199323};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH +
CC succinate; Xref=Rhea:RHEA:13213, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, ChEBI:CHEBI:57706,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.79;
CC Evidence={ECO:0000256|ARBA:ARBA00036722};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; FONG01000037; SFF91655.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2MJG0; -.
DR STRING; 380248.SAMN05216251_13723; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000199323; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07101; ALDH_SSADH2_GabD2; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11699:SF202; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP(+)] 2-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000199323}.
FT DOMAIN 36..492
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 528 AA; 56312 MW; 3DC89D65A9C20EE4 CRC64;
MTTTDTGRVK AALPTSLTPA RLGRLATLVA AGARAQRVAT TSPFTGAPLA DLPVSTPDDV
EDAFARARAA QAAWAATPVA DRKRIMLRFH DLVLQRQEEA LDLMQAESGK TRRDAFLEVS
DIAITARYYA RSARRLLSPK RRKGAIPVLT HTTELHHPKG VVTVISPWNY PLSMAAGDAI
PALMAGNAVV QKPDTQTALT ALWALALMRE ADLPADVWQM VVGRGSSIGD ALMAGADYMM
FTGSTASGRR IARNAGERLI GASLELGGKN AMIVLADADI EKAAVGAVAA CFPSAGQLCV
SIERLYVADE IHDAFVTAFV ERVRAVRLGG AYDFSVDMGS LTTPSQLETV SSHVDDAVSK
GATVLAGGKA RPDLGPLFYE PTILAHVTPQ MTLFDRETFG PVVSIYRYRS VEEAVEMANA
TPYGLNASVW GRNTARARKV AGRLHAGTVN VNEAFAAAWG SIDAPMGGMG DSGLGRRHGA
DGLLKYTEAQ TVAHQRLQGF TAPRGVGHEQ WTQILTRAFK TLRTLGVR
//