ID A0A1I2MKH1_9ACTN Unreviewed; 752 AA.
AC A0A1I2MKH1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Diguanylate cyclase (GGDEF) domain-containing protein {ECO:0000313|EMBL:SFF91942.1};
GN ORFNames=SAMN05421541_1312 {ECO:0000313|EMBL:SFF91942.1};
OS Actinoplanes philippinensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=35752 {ECO:0000313|EMBL:SFF91942.1, ECO:0000313|Proteomes:UP000199645};
RN [1] {ECO:0000313|EMBL:SFF91942.1, ECO:0000313|Proteomes:UP000199645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43019 {ECO:0000313|EMBL:SFF91942.1,
RC ECO:0000313|Proteomes:UP000199645};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FONV01000031; SFF91942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2MKH1; -.
DR STRING; 35752.SAMN05421541_1312; -.
DR Proteomes; UP000199645; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199645};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..484
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 493..748
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 752 AA; 78572 MW; 55D3BD22376FC85B CRC64;
MASTTPLLRW RSWYVPFAVL MAVADVLLIV LGTRTGFHRL VVWVPAVCGV ATAVASFAAT
ARDADGPLAA FWRRVAVAMG AVLAGAVSHT VDVALIPFDG MPPLGARTLL CYVVGTLLAI
VALLRLPGGG RSWRQLTTAL LDLAVVAVTA GVAASEYLGW AVGRFGGQAS AWWLNLAMVA
IGVAGVTVVV KIMSASRSPA ARAALWWLSP IGIAGPLSMI LMTVLLPWPH LNGSAVVLPF
VGLFGTLAAY AQQRVLTGHG ASSARVAHPA VYRRGAAIPL FATGMTSLLV GVVYLRTGHL
TTIQVGGTTL LLLLVVARQA LALAENATLL ETVAHQAMHD ELTGLYGRRS FAASVAGAEG
PHTVVLIDLK DFRSINDSLG AGAGDALLTG YARRLTAIAG EQAVVARLGG DEFGLLLPGA
PDATAGTVAR LVAAGDEPLS AAGHEVVVEV SIGIADDTDL YRRAEIALRE AAGHADARVV
RYDASLERQI NQRATIAADL RRGLHTGEFH MVYQPIVALP HGLITGVESL IRWTRADGRT
ISPADFVPVA EETGLIVELG EWIVDAVCAQ AADWHRRYGP DVLGSVGVNV SARQLLDPGL
PDMVASALAR HGLPAQHLTV EITETAVFGG GRALASVQAL SDLGVRIALD DFGTGHSSLG
LLRTCPVDVI KVDKSFVDGL NGTPQQEAIA GAIADIAEKM ELSTVAEGVE RPEQARRLFE
LGYRRAQGFL FARPMSAAGI DALLDPGVGV AA
//
