ID   A0A1I2MY31_9SPHN        Unreviewed;       416 AA.
AC   A0A1I2MY31;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SFF96484.1};
GN   ORFNames=SAMN05518801_104208 {ECO:0000313|EMBL:SFF96484.1};
OS   Novosphingobium sp. CF614.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=1884364 {ECO:0000313|EMBL:SFF96484.1, ECO:0000313|Proteomes:UP000199304};
RN   [1] {ECO:0000313|EMBL:SFF96484.1, ECO:0000313|Proteomes:UP000199304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF614 {ECO:0000313|EMBL:SFF96484.1,
RC   ECO:0000313|Proteomes:UP000199304};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; FOOR01000004; SFF96484.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2MY31; -.
DR   STRING; 1884364.SAMN05518801_104208; -.
DR   OrthoDB; 9764638at2; -.
DR   Proteomes; UP000199304; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR   PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199304};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SFF96484.1}.
FT   DOMAIN          5..234
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          293..415
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        92
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        372
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        402
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   416 AA;  43100 MW;  49A96F603D08C7E8 CRC64;
     MAEAYIIDAV RTPRGIGKKG KGALADTLPQ HLAATVLKAI KERNNLPEDA VEDVIWGTSA
     QYGLQAADLG RMAALDAGLG VGTSGVTLDR FCGSSLTATN LAAATIMSGM EDLLIAGGAE
     MTSFTADFGG RMREAGFSLG LGGANPRLQA KFPQTHQGVA ADAIAANEGI PRAALDAFGA
     ESQRRAAVAI QEGRFAKSLV PVIDDEGNVV LDHEEYPRPN TTAEGLAELK PAFAMFVDMP
     SAPDGPTFGG LINQVYPDIK IEPVHHAGTS SGNVDGASAL LLASEAAVKK YGLKPRARIV
     AMANHGEHPT LMLTAPSGAV TKVLAKAGLT KDDIDVWEIN EAFAAIVEKV IRDHDIDRAK
     VNPNGGAIAL GHPIGATGTI LVGTALDELE RTGGRYGLIT MCTAGGMAPA LIIERV
//