ID A0A1I2PCY3_9SPHN Unreviewed; 230 AA.
AC A0A1I2PCY3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=(S)-2-haloacid dehalogenase {ECO:0000256|RuleBase:RU368077};
DE EC=3.8.1.2 {ECO:0000256|RuleBase:RU368077};
DE AltName: Full=2-haloalkanoic acid dehalogenase {ECO:0000256|RuleBase:RU368077};
DE AltName: Full=Halocarboxylic acid halidohydrolase {ECO:0000256|RuleBase:RU368077};
DE AltName: Full=L-2-haloacid dehalogenase {ECO:0000256|RuleBase:RU368077};
GN ORFNames=SAMN05518801_107191 {ECO:0000313|EMBL:SFG11311.1};
OS Novosphingobium sp. CF614.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1884364 {ECO:0000313|EMBL:SFG11311.1, ECO:0000313|Proteomes:UP000199304};
RN [1] {ECO:0000313|EMBL:SFG11311.1, ECO:0000313|Proteomes:UP000199304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF614 {ECO:0000313|EMBL:SFG11311.1,
RC ECO:0000313|Proteomes:UP000199304};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydrolytic dehalogenation of small (S)-2-
CC haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic
CC acids. {ECO:0000256|RuleBase:RU368077}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a
CC halide anion + H(+); Xref=Rhea:RHEA:11192, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:58314,
CC ChEBI:CHEBI:137405; EC=3.8.1.2;
CC Evidence={ECO:0000256|RuleBase:RU368077};
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. S-2-
CC haloalkanoic acid dehalogenase family. {ECO:0000256|RuleBase:RU368077}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOOR01000007; SFG11311.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2PCY3; -.
DR STRING; 1884364.SAMN05518801_107191; -.
DR OrthoDB; 9785638at2; -.
DR Proteomes; UP000199304; Unassembled WGS sequence.
DR GO; GO:0018784; F:(S)-2-haloacid dehalogenase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.750; -; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006328; 2-HAD.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR023214; HAD_sf.
DR NCBIfam; TIGR01493; HAD-SF-IA-v2; 1.
DR NCBIfam; TIGR01428; HAD_type_II; 1.
DR PANTHER; PTHR43316:SF3; HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED; 1.
DR PANTHER; PTHR43316; HYDROLASE, HALOACID DELAHOGENASE-RELATED; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU368077};
KW Reference proteome {ECO:0000313|Proteomes:UP000199304}.
SQ SEQUENCE 230 AA; 25992 MW; 2123F4803C0414C0 CRC64;
MTSASPVFVP PFRPAYISFD CYGTLIRFRM SEMAREFFAD RIAPEAMDRM CQVFSTYRFD
ETMGPWQPYR ELIRNAVRRT ARKFGVEYRE ADADAIYEAV PTWGPHADVP GGLVRIADKI
PLVILSNAMN EQIPHNVALL GAPFHRVYTA ESAQAYKPRM QAFEYMFDQL GCGPEVMMHV
SSSFRYDQNT ATDLGFGCRV FVGRGHEPSN ASYRDVEIPH IGCLPAVVGL
//
