ID A0A1I2PJ42_9CLOT Unreviewed; 516 AA.
AC A0A1I2PJ42;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN ORFNames=SAMN04487885_12830 {ECO:0000313|EMBL:SFG14007.1};
OS Clostridium cadaveris.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1529 {ECO:0000313|EMBL:SFG14007.1, ECO:0000313|Proteomes:UP000182135};
RN [1] {ECO:0000313|EMBL:SFG14007.1, ECO:0000313|Proteomes:UP000182135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NLAE-zl-G419 {ECO:0000313|EMBL:SFG14007.1,
RC ECO:0000313|Proteomes:UP000182135};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; FOOE01000028; SFG14007.1; -; Genomic_DNA.
DR RefSeq; WP_027639663.1; NZ_JAUDCX010000019.1.
DR AlphaFoldDB; A0A1I2PJ42; -.
DR STRING; 1529.SAMN04487885_12830; -.
DR eggNOG; COG1620; Bacteria.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000182135; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000182135};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 60..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 103..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 400..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 497..515
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 516 AA; 54168 MW; BE7B14DE442060C8 CRC64;
MVIMFFLAML PIIWLIIALS GLKMPAFKAC PIALLLTIFL SLIVWKMPFM DMFTGALEGA
VMGIWPICLV IIAAIFTYNL TVYTKNMDLI KRMLTSVSMD KRILVLIIAW GFGGFMEGMA
GFGTAVAIPA SMLCGLGFNP IFAATVCLVA NATPTAFGSI GIPTITAASI TGLGASDVAI
AAVTQLALMI VITPFLMVIM TGKSLKSLKG VGLITLISGL AFVIPEFLTA KFVGAELPVV
IGSVCSMAAT ILASKFLAKK PAPDYVLEEI AADSEDTKIE SLTVSRAIRA WMPFILILVF
LLLTSSLIPP IHNVLSSIKT SIQIYSGAGA TKYTFTWVAT PGVLIFIAAI IGGRIQKASF
GEIFGVLGDS LKQMWKTVIT IVSILATAKL MGYSGMINDI AALIVSITGS FYPLVAPLIG
SIGTFVTGSA TSSSVLFAGL QAQTAETLNM SPVWMAAANT AGATAGKIIS PQSIAIAVAA
ANTVGEESKI LNASIKYYII FIVVFGLIAF FGGGLI
//
