ID A0A1I2PSA6_9CORY Unreviewed; 439 AA.
AC A0A1I2PSA6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=O-acetylhomoserine (Thiol)-lyase {ECO:0000313|EMBL:SFG18500.1};
GN ORFNames=SAMN05660282_00184 {ECO:0000313|EMBL:SFG18500.1};
OS Corynebacterium spheniscorum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=185761 {ECO:0000313|EMBL:SFG18500.1, ECO:0000313|Proteomes:UP000199065};
RN [1] {ECO:0000313|EMBL:SFG18500.1, ECO:0000313|Proteomes:UP000199065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J11, PG 39 {ECO:0000313|Proteomes:UP000199065};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; FOPJ01000001; SFG18500.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2PSA6; -.
DR STRING; 185761.SAMN05660282_00184; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000199065; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Lyase {ECO:0000313|EMBL:SFG18500.1};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000199065}.
FT MOD_RES 217
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 439 AA; 47120 MW; 32EC2A2FBA8527BF CRC64;
MTTRYDNSAA NTWGLATRAI HAGQQVDSDT SSRNQPIYLS SSFVFNSAEH AKQRFALEDL
GPVYSRLTNP TLDALENRLA SLEGGVHAVA FASGQAAETA AILNLASAGD HIVSSPRLYG
GTETLFLATL ARLGIEVSFV ENPDDPESWQ AAVKENTKAF YGETFANPQA DVLDIPAIAE
VAHRNSVPLI VDNTVATAAL VRPLELGADI VVASLTKFYT GNGSGLGGVL VDGGSFDWTV
EKDGKPVFPH FVTPDPAYHG LRYADLGEAA FGLKARVGLL RDTGATLSPF NAWVTLQGLD
TLLLRVNKHN ENAEKVARFL KEQPQVTRVN YAGLEDSPWY EVKQKLGLKY TGSVISFDLE
GGREQAWAFI DALKLHSNLA NIGDVRSLVV HPASTTHSQS DEKGLARAGV SQSTIRLSVG
IEDIEDILAD LKSGFEAIS
//
