ID A0A1I2QC29_9CORY Unreviewed; 3039 AA.
AC A0A1I2QC29;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Fatty acid synthase, bacterial type {ECO:0000313|EMBL:SFG25858.1};
GN ORFNames=SAMN05660282_00384 {ECO:0000313|EMBL:SFG25858.1};
OS Corynebacterium spheniscorum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=185761 {ECO:0000313|EMBL:SFG25858.1, ECO:0000313|Proteomes:UP000199065};
RN [1] {ECO:0000313|EMBL:SFG25858.1, ECO:0000313|Proteomes:UP000199065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J11, PG 39 {ECO:0000313|Proteomes:UP000199065};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
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DR EMBL; FOPJ01000002; SFG25858.1; -; Genomic_DNA.
DR STRING; 185761.SAMN05660282_00384; -.
DR Proteomes; UP000199065; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.2430; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 6.10.140.1400; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR040899; Fas_alpha_ACP.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF18325; Fas_alpha_ACP; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199065}.
FT DOMAIN 2494..2949
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1148..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3039 AA; 323495 MW; 85BDADC6F50DB2CA CRC64;
MSDQHKALNP EQPRLNQRLL EEGAGFALAY AGQGQPWLST LADNLHASTE VHDAVAMAVK
GANAMVQPVA DELAAARPEG FKPVAWAEER IDAPTDEYQP AYSVPGITVA QMAVTYALRA
QGLPTEAAKA VIAHSQGVLA AYPMQGRCDD ATAIALAELI GVAMTRQGRI SGLIAGNGAA
GISPMVAIGG VSKDIVEYAI AKAKVSSVVG LVNSREDVVM VGRPADNATV IRLLKAQSAK
EQKELDDKRR GGTALNPRFT QLEVRAGFHH PDMQAGADQV VQWAERCGID IELARDAAQA
VMVTPVDWPR EIAAVVDAGA TWVLDLGPGR GVQSLTAKIL RGRGVGSLAV ADSEGQADLF
DAGRKLKEPL DYSEYLPKVV DVHGQKRLRT KFTELTGQSP MLLAGMTPTT VDAEIVAAAA
NSGHWAELAG GGQVRQNILE RSIEKLSGLL DEGVSASFNA MFLDPKLWGL HIGGRKLVQK
ARQAGAPIDS IVVSAGMPEP EEAELLLAEL EANGFNHVAF KPGAVNQIRR VLALADRVPE
TPIIMQVEGG KAGGHHSWED LDDLLIATYE DIRRRPNVVL CVGGGIGTPE RAADYLTGQW
AKPYALPLMP VDGILIGTAA MAAKEAKTSP QVKRALVEAQ GDPNAWVPAG RAVHGVASGR
SQLGADIHEI ENSFAKAGRL LDEVAGDAEA VAKRREEIIA AINKTCKPYF GDVQTMSYAQ
LIRRYLELSG PYDAEAAAAV ELPEEDHGWV NRAWFTRFAE LIERTEARLS PVDSGEFDAQ
VETRIDKDPQ ETLQELLAAY PAAEDQVLHP ADVDWFYALC VSSGKPVNFV PVIDKDVRRR
WRSDSLWQAH DPRYEADEVC IIPGPAAVAG ITKMDEPIAE LLGRFDQASI ERILESGAEV
SEDRTPVIRQ ILNARTTEWA GRQQRSLIHR LGAPETWEEK GEGFYHPESG ATLESSASGA
MLNVPLTDGE LKVPYRLSAG APGGVVPTVS AHDAEESMAA LTKVAAGGQL AEANGLKAHW
ETQIQAAKLA DYATVTTGHL GSNTVHVDAD QLTPDVLVGY AWPAIFSAVR ASGAVEGMLS
LVHLDHQIAV EEDLDGLSDG ITLVIDAEAQ EPVDTEMGRV VMVKATINAR HKTIATLKER
FLVRGRTGTD PMPQWADEAT SENTATDTPR SFRAATTVQA PRSMRSFAIV SGDRNPIHVD
QAAAALAGLG EPIVHGMWTS AIAQIVAAAG YEGEETTTAP GVVKEWSASM IAPVLPGATV
DIQVDRIGVD SRPGYGEIRN VTATVDGQPV LSATATMAAP VTFYAFPGQG IQSQGMGMAS
RASSAAARAV WDRADKHTRE KLGFSVLHIV QDNPQDVWVD GEKFSHPDGV LYLTQFTQVA
MATLGVAQVA EMEEAGVMED HSYFAGHSVG EYDALSAYSG VLSLESVVEI VYRRGLTMHR
LVERDENGLS TYGLAALRPN KMGLSEDEVF DYVTEMSEKC GEFLEIVNYN IAGVQYAVAG
TVKGLSAMQA DVEKRAPGQR AYIRIPGIDV PFHSSKLRDG VGDFREHLNA LLPETFNLDR
LIGRYIPNLV ARPFELSYEF VESMTEVVDS EIINGILENF EEASKDEHVL ARTILVELLA
WQFASPVRWI ETQALALEDL GVQRFIEVGV GDSPTIANMM GQTLRLPRYA GHPIEVLNVE
RDRPVVFASD EISRALPEVD AEAEGTDVQA SVSAADSSTA EASAAAPAAA PAAATTAPAA
SAPAATGGAR PDDLLLSAGE ATEMLIAVWT KVRPDQMTPT DSIETLVEGV SSRRNQLLLD
LGVEFGLGAI DGAADAALED LKAQVAGLAR GYKAFGPVLG EASADALRRL TGPTGKKPTY
IRERVTGTWE LGEGWADQVT AALVLGTREG ASLRGGELAT LQPANPSKAA DLDELIDAAV
QAVAAQHGVS VSLPSAGGGA GGAVVDSAAL NEFAENLTGK DGILAQTARD LLERLGLQDQ
ADALVDAGAD DRAIVALVER ELGADWPKQV APSFNPDKAV LLDDRWASAR EDLSRAVLNS
TTDDLDLHGA GEAVAAQAEY LGYPELAAQA RNEEPLRYSA DTAVVTGGSP NSIAASIIAQ
LLHGGATVVA TTSSLNHKRL EFYKKLYANN ARGNAALWVA PANLSSYEDL DNLVEWIGNE
QTATVNGAKK VLKKPLIPTL LFPFAAPGVS GSVDDAGPQA ESQMRLLLWS VERLVAGLSH
IGSDVSVGHR LHVVLPGSPN RGRFGGDGAY GESKAALDAL VTRWKAEQPG WGERTSLVHA
HIGWIRGTGL MGHNDVLVDE VEKAGVRTFS TEEITEKLLS QATPEVRNQA AQAPITVDYT
GGLAEAELNL PELARTAREK AEASDAAEAS TTTPRTIAAL PSIRQPLQWT NPTFQPVQRS
LDDMVVMVGV GELSPLGSSR TRFEVELGDT LSAAGVTELA WSMGLISYED GAWRDSDGEE
VPETEIRERY LDEVMAKIGV RQFHDDFHMV DNLAPELTQV YLDRDLTFAA ADEAEARSFL
EAEPDTTRIA FDGDTEEWLV TRTAGAAVRV PRRVVMTRFV GGQIPEGFDP AVWGIPADMI
DNLDRVAVWN LVCTVDAFLS SGFSPADILG AVHPGRVSST QGTGMGGVQS MRSLYIDGLL
AEPRANDILQ EALPNVVAAH VMQSYVGGYG QMIHPVAACA TAAVSVEEGS DKIRLGKADF
VVAGGIDDLS IEGITGFGDM AATADSAEMR AKGIDDRYFS RANDRRRGGF IESEGGGTVL
LARGSFAADY NLPVLAVVGY AESFADGAHT SIPAPGLGAL GAARGGQHSG LGRSLAALGL
NADDIAVISK HDTSTTANDP NESDLHERIA GALGRSDGNP LYVISQKTIT GHAKGGAAAF
QLGGLAQVLR CGTIPANRSL DCVDPVLRKH QHLVWLRQPL ALSGALTPKA GLVTSLGFGH
VSALIMLAHP GVFLTALAQE RGCEAAEAWQ AAARGKEYRG LQLILGGMHQ VNPLYQRPQD
RHLGGTDDAA KEREAAVLLD DRARLVDGIL TIPEEEEQA
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