ID A0A1I2T2U5_9FIRM Unreviewed; 541 AA.
AC A0A1I2T2U5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:SFG56746.1};
GN ORFNames=SAMN04487761_12723 {ECO:0000313|EMBL:SFG56746.1};
OS Lachnospiraceae bacterium C7.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1792306 {ECO:0000313|EMBL:SFG56746.1, ECO:0000313|Proteomes:UP000198643};
RN [1] {ECO:0000313|EMBL:SFG56746.1, ECO:0000313|Proteomes:UP000198643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C7 {ECO:0000313|EMBL:SFG56746.1,
RC ECO:0000313|Proteomes:UP000198643};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOPE01000027; SFG56746.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2T2U5; -.
DR STRING; 1792306.SAMN04487761_12723; -.
DR Proteomes; UP000198643; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030572; F:phosphatidyltransferase activity; IEA:UniProt.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:UniProt.
DR CDD; cd09154; PLDc_SMU_988_like_1; 1.
DR CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198643};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..272
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 454..481
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 541 AA; 63640 MW; D0E0F0F1ABFC2746 CRC64;
MNKFLSRLFG RLSLTFLAIV IQFCWMVFLV YLFSEKVEYV NIFIHIMSAV LAVIVLNRDI
QPYNKVSWIL LILCLPIFGC MCYYIFGRPE LTKKNRRKLY RTHKFYEKYY DENQKELEQV
KQENYYAYKQ ARYISKYGDY PIYQSDDIEY FSKVENLFPK LLEDLENAKR FIFLEFFIVD
EGYMLDKIME ILTRKVKEGV EVRFIYDDVG CVNTMSRKKW ADLEKRTGVK FAMFNKFKPV
MSVVMNNRDH RKIVVIDGKT CYTGGFNLAD EYINKIERFG YWKDSGVRFA GKPVKNYTLM
FLEMWNYING TFEDADFYIN MYENTQSISK DSAENSIKNN INQDNIAQEN INQDNIAQKN
AYIQPYGDSP LDHEYVGENV YMTMINNAKE YVYIFTPYLI IGSELTQSLI NAAKSGVDVR
IVTPGIPDKK AVFLLTQSSY EPLIEAGVKM YQYTPGFIHA KCCISDDESG IVGTINFDFR
SLYMHFECAV SMFKCSAIKS LKKDFIETFE KSELISIEFT KKRDYIVRFW QSILRAFAPL
L
//
