ID A0A1I2TLA2_9FIRM Unreviewed; 607 AA.
AC A0A1I2TLA2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05660649_02290 {ECO:0000313|EMBL:SFG64919.1};
OS Desulfotruncus arcticus DSM 17038.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfotruncus.
OX NCBI_TaxID=1121424 {ECO:0000313|EMBL:SFG64919.1, ECO:0000313|Proteomes:UP000199337};
RN [1] {ECO:0000313|Proteomes:UP000199337}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17038 {ECO:0000313|Proteomes:UP000199337};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FOOX01000007; SFG64919.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2TLA2; -.
DR STRING; 341036.SAMN05660649_02290; -.
DR Proteomes; UP000199337; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SFG64919.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199337};
KW Transferase {ECO:0000313|EMBL:SFG64919.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..387
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 400..605
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 607 AA; 67904 MW; BE39A2189B81FC95 CRC64;
MMSNKNIFFG NRILLVVSLL LFLTVMLTVY LMSIIRNSEL SLLHHQNARL DQVAYLFDQN
LEGSLRDYLA KQNLNGDDRE KQVVALGNYI NGVINEVRRE YPDVHIGLWY TDLDVYYDGT
QRFGENYSLR RKKVFEAVLE QKSAVEQNVG EEEGGIVEVY KPFTRNGQVE GVIRSAEYLG
ETTYYAKRRE IEYTVYSLIA MVVITGTTGA VLIFRQLVSQ VESIKNGVKL LENDLNQTLE
PAPGELGVIV EAVNGFAHKI ADLNIYNETM LASIDDAILV VDVDGKIMIA NNMARRLMFL
PDDYRDKAYH ELLPAGGPFV ELINKTLDDK INYKDLHLSW ANNGGGSVVE LLISTAVLVG
AKGREIGVVL LCRDITERMR LREKAQRQER LASLGKLVTG VAHEIRNPLT SISIYMQHWQ
NQSTPSPKAL ATINREVARL DAIVDQLLYF AKPAEAKLVP KDINSLIESV LSFFNEIHHG
KYSLIRNLDP NVPQVWIDPE QIERVLVNML FNAIQAMPEG GTITVSTGDN KVDGMVNVSI
ADTGCGIAKE HHGHLFDPFY STRPKGTGLG LAIAHEIIQV HGGHIEVDSE VGKGTEFTFY
LKTGEDV
//
