ID A0A1I2V4T3_9CORY Unreviewed; 498 AA.
AC A0A1I2V4T3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Transporter, NhaC family (TC 2.A.35) {ECO:0000313|EMBL:SFG84424.1};
GN ORFNames=SAMN05660282_02134 {ECO:0000313|EMBL:SFG84424.1};
OS Corynebacterium spheniscorum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=185761 {ECO:0000313|EMBL:SFG84424.1, ECO:0000313|Proteomes:UP000199065};
RN [1] {ECO:0000313|EMBL:SFG84424.1, ECO:0000313|Proteomes:UP000199065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J11, PG 39 {ECO:0000313|Proteomes:UP000199065};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; FOPJ01000018; SFG84424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2V4T3; -.
DR STRING; 185761.SAMN05660282_02134; -.
DR Proteomes; UP000199065; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199065};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..484
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT REGION 9..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 52136 MW; EA1467AC569219C5 CRC64;
MRCAGSVEIV NKHGNPEEQE SPPEARTLAP KRSGEADPSI LSAAITVATV VLLISIGLVV
FEADLHLLMA GALLIVSVSA MSFARRTPED IVRAMAQGIW EAKGALVIFV LIGALIAALM
ASGTVATLID AGLRLIQPGW FLPAALVLCC LMSIATGTAW GTAGTAGVVL MGIGAASGLP
LPLVAGVVVS GACFGDKMSP ISDTTNLAAM AARTGLYQHI RSMLMTTGPT FVLVLIAYGL
AGRHFGAKVI PADDVQVFSD AIGATYVLGW VTLLPLAVMV GLSLLRVDAR MSMAVTILVA
GGVAMLVQHV AVGDWLQALW RPAGVDTGVE VLDGLFGRGG VTSMWWTLML SLEALALGGV
LSRFGYVRVL IHGMLGAIRR VGSLVSATII GALLCNIGMG EAYMSIILGG QLFREKYEEM
GIDSAVLSRS LEEGATLTTP LIPWTTAGIF FAATLGVPTL NFLPYAWLNL LNPLVGIAFA
YLGWGLWRRR KTPLNAMA
//
