ID   A0A1I2X375_9FIRM        Unreviewed;       611 AA.
AC   A0A1I2X375;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SFH07379.1};
GN   ORFNames=SAMN05660649_03762 {ECO:0000313|EMBL:SFH07379.1};
OS   Desulfotruncus arcticus DSM 17038.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC   Desulfotruncus.
OX   NCBI_TaxID=1121424 {ECO:0000313|EMBL:SFH07379.1, ECO:0000313|Proteomes:UP000199337};
RN   [1] {ECO:0000313|Proteomes:UP000199337}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17038 {ECO:0000313|Proteomes:UP000199337};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
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DR   EMBL; FOOX01000015; SFH07379.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2X375; -.
DR   STRING; 341036.SAMN05660649_03762; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000199337; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199337};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        40..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          280..563
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   611 AA;  68062 MW;  357AE481E9D644D9 CRC64;
     MNSAVRFISL LVVDFIIINL SFICSYIVRF EQVEALLPNL VNYLQISPVI ILIFLACFCY
     FKIYKRVWAY ASIGELITIV QAVTAGSVIV IVLTYLTGAM LPRSIVLTSW AFIILLLGSS
     RLCWRLHLEV RKNSCRKGKN TLIVGAGDAG VLVAKELKNH DSGLVPVGFI DDDPNKWRLS
     VLSLPVFGNR EKIEKTVNKH NVQLIIIAMP SADARQIKQI FEICRKTNKE VKILPGYYQL
     IDGNVKINQL RPVKIEDLLH REPVKLNLNE ISGYIKGETV LITGAGGSIG SELCRQAAGF
     KPKLLVILGH GENSIHKIWL ELQEKFKDIP LGVEIADVRD KQKINSVFQK YRPAVVFHAA
     AHKHVPLMEY HPDEAVKTNV LGTYNVVEAA DRAGTKQFVL ISTDKAVNPS SVMGATKRLA
     ELIIQNADKT SNTKFVAVRF GNVLGSRGSV VPIFEEQIKK GGPVTVTHPK MKRYFMTIPE
     AVQLVIQAGS MADGGEIFIL DMGKPVKIVD LARDMIKLSG LEPDKDIEIK FTGVRPGEKL
     FEELLTEQEG VASTTHKRIF VAKPCLFELA ELEKQLLYIS ANANNIDDKI IFAILDLIIP
     NFKNYRDKLV G
//