ID A0A1I2X641_9SPHI Unreviewed; 395 AA.
AC A0A1I2X641;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=23S rRNA (Cytosine1962-C5)-methyltransferase {ECO:0000313|EMBL:SFH08985.1};
GN ORFNames=SAMN04489864_10520 {ECO:0000313|EMBL:SFH08985.1};
OS Pedobacter insulae.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=414048 {ECO:0000313|EMBL:SFH08985.1, ECO:0000313|Proteomes:UP000199666};
RN [1] {ECO:0000313|EMBL:SFH08985.1, ECO:0000313|Proteomes:UP000199666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18684 {ECO:0000313|EMBL:SFH08985.1,
RC ECO:0000313|Proteomes:UP000199666};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmI family.
CC {ECO:0000256|ARBA:ARBA00038091}.
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DR EMBL; FOPP01000005; SFH08985.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2X641; -.
DR STRING; 414048.SAMN04489864_10520; -.
DR OrthoDB; 9805492at2; -.
DR Proteomes; UP000199666; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd21153; PUA_RlmI; 1.
DR CDD; cd11572; RlmI_M_like; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR Gene3D; 3.30.750.80; RNA methyltransferase domain (HRMD) like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR041532; RlmI-like_PUA.
DR InterPro; IPR019614; SAM-dep_methyl-trfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42873:SF1; METHYLTRANS_SAM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42873; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE; 1.
DR Pfam; PF10672; Methyltrans_SAM; 1.
DR Pfam; PF17785; PUA_3; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFH08985.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199666};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFH08985.1}.
FT DOMAIN 4..67
FT /note="RlmI-like PUA"
FT /evidence="ECO:0000259|Pfam:PF17785"
FT DOMAIN 169..337
FT /note="S-adenosylmethionine-dependent methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF10672"
SQ SEQUENCE 395 AA; 43748 MW; 6BCCCE7857D8EFCC CRC64;
MVEIRLKKGK EKAVLQLHPW VFSGALDKIM GSPVNGEVVK VISANNEFLA YGYFNDQSRV
AIRLLEWNEG VMIDEEWYAK KINAAISSRA QLLANAETNA YRLIFSEADF LPGLIVDKYA
DFLSVQILSS GIESAKSIII RILCDTLQPK GIFDRSDATA RTHEGITAEN GLLWGEAPAE
FIAVKENGIT YHINIAEGQK SGFYCDQRDN RRILAEYAAG KSVLDCFSYS GGFSLNAFKN
HAKEVFSVDS SALAIETLKQ NIALNKFDQN IHTAIQSDVN KQLRAFKEEG KKFDIVVLDP
PKYAPSRSAL DRAARAYKDL NRLGLSLLES GGLLATFSCS GAVDIETFKQ IIAWAALDAG
KEVQVIKQFS QPEDHPVRLS FPEGEYLKGL LVRVV
//
