ID A0A1I2Z233_9FIRM Unreviewed; 529 AA.
AC A0A1I2Z233;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05660649_04719 {ECO:0000313|EMBL:SFH31770.1};
OS Desulfotruncus arcticus DSM 17038.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfotruncus.
OX NCBI_TaxID=1121424 {ECO:0000313|EMBL:SFH31770.1, ECO:0000313|Proteomes:UP000199337};
RN [1] {ECO:0000313|Proteomes:UP000199337}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17038 {ECO:0000313|Proteomes:UP000199337};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FOOX01000024; SFH31770.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I2Z233; -.
DR STRING; 341036.SAMN05660649_04719; -.
DR Proteomes; UP000199337; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFH31770.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199337};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFH31770.1}.
FT DOMAIN 4..162
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 529 AA; 59656 MW; 86621D2BB8715018 CRC64;
MSSDARARGA YYTRLNIARY LARWAIRKAT DTVLEPSFGN GAFIDAALER LEELGGSKQN
LFAVEVHQET YQNFLSNQSI NPENFVNADF LSVESCFPID TVIGNPPYVR LRHLDISSAR
LAIARTEAAG VKMTRDGSLW MPFTVHACSF LKPGGRLALV LPFEITHVKY AIPLWEFFSR
SFEHITVIRT HEDLFPGIEE ETVLLLAENY TKTTDFVQHR VYLTHHDLLN NVPYRLAAIP
LETIYHRQKP FVKSLLEPDL RHLLSDLACY GTTVPLQAIC KFKIGYVTGD KHFFHPDRDI
KKKYGLPPLN LINTVKNSRQ LRGRGLFLSD PVSETSLYYP VAITAEDRSY IKFGEKTGIN
NRYKCKARHP WYLTPGIEIP DVILTVFSET PILVLNSAGF AASNSLLCGF LKDPATNPED
FACRWYNSLV LLSIELNIHS LGGGVLVLIP GEVNNLLFPA ISPGKGKHAF LKKIDFCLKA
EQTAKAYQAG DQFLLQNCLG LTPGQIELIK NGIATLQHWR KPHNKRKKK
//
