ID   A0A1I2Z565_9MICO        Unreviewed;       829 AA.
AC   A0A1I2Z565;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=E3O11_13730 {ECO:0000313|EMBL:TFB82896.1};
OS   Cryobacterium levicorallinum.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Cryobacterium.
OX   NCBI_TaxID=995038 {ECO:0000313|EMBL:TFB82896.1, ECO:0000313|Proteomes:UP000297963};
RN   [1] {ECO:0000313|EMBL:TFB82896.1, ECO:0000313|Proteomes:UP000297963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hh34 {ECO:0000313|EMBL:TFB82896.1,
RC   ECO:0000313|Proteomes:UP000297963};
RA   Liu Q., Xin Y.-H.;
RT   "Genomics of glacier-inhabiting Cryobacterium strains.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TFB82896.1}.
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DR   EMBL; SOFE01000023; TFB82896.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I2Z565; -.
DR   STRING; 995038.SAMN05216274_103166; -.
DR   Proteomes; UP000297963; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:TFB82896.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          22..475
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   829 AA;  89023 MW;  25157BE79B32D618 CRC64;
     MSRSDSTTPD TSTASTERIE DVDVSVEMQG SFLEYAYSVI YSRALPDARD GLKPVQRRIL
     YQMNEMGLRP DKGHVKSARV VGEVMGKLHP HGDTAIYDAL VRMAQSFSLR VPLIDGHGNF
     GSLDDGPAAP RYTEARLAAP ALAMTENLDE DVVDFVPNYD NQLTQPDVLP AAYPNLLVNG
     TSGIAVGMAT NMAPHNLIEV VGAARHLLAH PNATLDDVME FVPGPDLPTG GTIVGLAGIK
     DAYSTGRGSF KTRARVSVES ISARKTGLVV TELPYLVGPE KVIEKIKDGV NSKKLSGISD
     VTDLTDRTKG LRLVIGIKTG FSPDAVLEQL YRYTPLEDSF NINAVALVNG APQTLGLLEL
     LHVYVNHRIE VVTRRSAYRL ARRKERLHLV LGLLVAILDI DEVIQVIRAS DDTEQARAKL
     IDVFDLSQIQ AEYILELRLR RLTKFSRIEL EAERDQLVAE IAKLEKLLSS KAAIRSLVSE
     ELGAVAEKFG TPRRTVLTEA KPSIAGLSVA AAKRQAAVLE VQDIATRIFL SATGRIARVD
     LVAVDDSLPQ RIQPPQRRSK HDAVLSTLDT TSRTEVGAVT NRGRLIRFSP VDLPVMPPTS
     IQLAAGVRIS EYLVLSDKKE HVLGIISLDS DRAIALATRQ GVVKRVTPGD WANKPDFEIV
     ALKPKDEVVG AVQGGEDDDL VFITSDAQLL RFTASGVRPQ GRAAGGMAGI KLAPGETVVF
     FTSLSTDDVA TAIVATVAAS SQTLPGTDPG SAKLSDFSEY PAKGRATGGV RAQRFLKGED
     TLAVAWVGPA PARAVGPDGT PRALPESGSR RDASGVMLDA IIGAIGSEI
//