ID A0A1I3AT04_9MICO Unreviewed; 1000 AA.
AC A0A1I3AT04;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Na+/H+ antiporter subunit A {ECO:0000313|EMBL:TFB87993.1};
GN ORFNames=E3O11_02635 {ECO:0000313|EMBL:TFB87993.1};
OS Cryobacterium levicorallinum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Cryobacterium.
OX NCBI_TaxID=995038 {ECO:0000313|EMBL:TFB87993.1, ECO:0000313|Proteomes:UP000297963};
RN [1] {ECO:0000313|EMBL:TFB87993.1, ECO:0000313|Proteomes:UP000297963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hh34 {ECO:0000313|EMBL:TFB87993.1,
RC ECO:0000313|Proteomes:UP000297963};
RA Liu Q., Xin Y.-H.;
RT "Genomics of glacier-inhabiting Cryobacterium strains.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFB87993.1}.
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DR EMBL; SOFE01000004; TFB87993.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3AT04; -.
DR STRING; 995038.SAMN05216274_107106; -.
DR Proteomes; UP000297963; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 61..108
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 125..399
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 606..670
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 680..760
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 821..942
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 1000 AA; 105897 MW; B619682759D292A2 CRC64;
MVQFLLAFVV LSVLTPWLTR RVGTRVFYLI ALLPAGAFAY TLTQTATVTA GGAVTQSIPW
IPQLGISLSL RVDTLAWLLA LVVTGVGALV LIYCARYFTD DEPSLGRFAA LLLAFAGTMY
GLVTADDLVI MFMFWEITSV LSYLLIGHYT HKRESRGAAL QALIVTTFGG LVMLVGVVMI
SVASGTTSLA YIVANPVTST MGTWAILLIL VGALSKSALV PFHFWLPAAM AAPTPVSAYL
HAAAMVKAGI YIVARLAPGY ADSAGWLPVL VTLGVWTMVV GAWRALRQYD LKLLLAYGTV
SQLGFLMIAI GFNTRDTALA GAALLLAHAL YKATLFLVVG VIDHRAGTRD WRKLSGVGRS
APALALIALV AVASMAGLPP LFGFVAKEAV FTSLFDAGVG GSGWGYAALI GTAVGSVLTV
AYSIRFFWGA FGTRREQPDT VLHASPWDTL LAPGVLTVAT IGLGLFAALL DPLLAPYADT
VPGAGSITEP PYHLALWHGF EPALYLSAVV LLLGALLFRA RRGVSKLQAR VPDVIDASRG
YGKAIRSVDR VAARVTHFAQ QGGLPQYLGT ILSVFVVALG FAAFVNRTWP ETIVLWDYPG
QVLIALIMAI CAVMAARVGQ RMTAVILAGV TGYGLVALFA FHGAPDLALT QALVESITLV
IFVLVLRRLP ANIAQHNKPV RRKRRLLIGS LVGLVMGTIG FIALGARDFA SIAGALPRLS
VDDGHGDNIV NVMLVDIRAW DTMGEVSVLI VVATGVASLL FVSGRYSVLP RLKESRSLRA
GANRRRIVAD PELSSEGHAV TRQAFLLAGR KNDPRNRSIL IEVLVRLLFH PAMIVSIYLL
FAGHNLPGGG FAGGLLAGLA LVARYLAGGR YELSEAAPID PGKILGLGVI LAVGMAVVSL
FFDGIPLESA YFTATVPVLG DLSFGTSTIF DIGVYLVVIG LTYDILRSLG SEIDRQSEND
EIGPRPAPDD TAAPAEPSTD TAAGLNIHPL HEIPNGGGTR
//
