ID A0A1I3C3B9_9BRAD Unreviewed; 315 AA.
AC A0A1I3C3B9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Lactate dehydrogenase {ECO:0000313|EMBL:SFH68826.1};
GN ORFNames=SAMN05216525_101299 {ECO:0000313|EMBL:SFH68826.1};
OS Bradyrhizobium sp. Gha.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=1855318 {ECO:0000313|EMBL:SFH68826.1, ECO:0000313|Proteomes:UP000199284};
RN [1] {ECO:0000313|EMBL:SFH68826.1, ECO:0000313|Proteomes:UP000199284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gha {ECO:0000313|EMBL:SFH68826.1,
RC ECO:0000313|Proteomes:UP000199284};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FOQM01000001; SFH68826.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3C3B9; -.
DR STRING; 1855318.SAMN05216525_101299; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000199284; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 28..314
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 109..283
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 315 AA; 34043 MW; B63B22DA594D0AAC CRC64;
MSNPEILQMG PYPEWDQIPL DAAYTVHRYF EASDRSALLA EVGSRVRAIA TRGELGANAE
LIAACPKLEI ISIYGVGFDA VHLESCRKRG IHVTNTPDVL TKDVADLAVA MMLAQWRGVN
AAERWVRDGS WVAKGLYPLK TRAWGKRAGV LGLGRIGFEV ARRLAGFDMD IAYSDVEAKP
HGKDWTFIAD PVALAERSDV LFVTLAASAA TRHIVGRNVL QALGPDGLLV NVSRASNIDE
EALIAALTDG TLGAAALDVF EGEPRLDPRF LELPNVLLQP HHASGTTETR KAMGQLMRDN
LAAHFAGLPP PTPVL
//
