ID   A0A1I3EP46_9PSED        Unreviewed;       268 AA.
AC   A0A1I3EP46;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=Lipopolysaccharide core heptose(I) kinase {ECO:0000256|PIRNR:PIRNR037318};
DE            EC=2.7.1.- {ECO:0000256|PIRNR:PIRNR037318};
GN   ORFNames=SAMN05216206_1053 {ECO:0000313|EMBL:SFI00600.1};
OS   Pseudomonas guineae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=425504 {ECO:0000313|EMBL:SFI00600.1, ECO:0000313|Proteomes:UP000243606};
RN   [1] {ECO:0000313|Proteomes:UP000243606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 24016 {ECO:0000313|Proteomes:UP000243606};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Kinase involved in the biosynthesis of the core
CC       oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the
CC       phosphorylation of heptose I (HepI), the first heptose added to the
CC       Kdo2-lipid A module. {ECO:0000256|PIRNR:PIRNR037318}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR037318}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/rfaP
CC       family. {ECO:0000256|PIRNR:PIRNR037318}.
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DR   EMBL; FOQL01000001; SFI00600.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I3EP46; -.
DR   STRING; 425504.SAMN05216206_1053; -.
DR   OrthoDB; 9782725at2; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000243606; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR017172; Lsacc_core_hep_kinase_RfaP.
DR   Pfam; PF06293; Kdo; 1.
DR   PIRSF; PIRSF037318; RfaP; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR037318};
KW   Kinase {ECO:0000256|PIRNR:PIRNR037318};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|PIRNR:PIRNR037318};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037318};
KW   Reference proteome {ECO:0000313|Proteomes:UP000243606};
KW   Transferase {ECO:0000256|PIRNR:PIRNR037318, ECO:0000313|EMBL:SFI00600.1}.
SQ   SEQUENCE   268 AA;  30849 MW;  715E59397925B31D CRC64;
     MKLLLAEPFK SLWADRDAFA AVEALQGQVY RELEGRRTLR AEVAGRGYFV KIHRGIGWGE
     IVKNLLTAKL PVLGARQEWQ AIERLHEAGV ATMTAVAYGE RGSNPAAQHS FIVTEELAPT
     IDLEQLSLNW AEQPPEPRLK WALIKEVANM VGSMHRAGVN HRDCYICHFL LHTDKPVTAD
     DFRLSVIDLH RAQVRRKLPL RWRNKDLAAL YFSVLDIGLT RRDKLRFLRD YFQQPLRQTL
     SNERSLLVWL ERKADALYAR KQRYGDAL
//