ID A0A1I3HAU1_9BACL Unreviewed; 812 AA.
AC A0A1I3HAU1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN02799624_00378 {ECO:0000313|EMBL:SFI32773.1};
OS Paenibacillus sp. UNC496MF.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1502753 {ECO:0000313|EMBL:SFI32773.1, ECO:0000313|Proteomes:UP000198714};
RN [1] {ECO:0000313|EMBL:SFI32773.1, ECO:0000313|Proteomes:UP000198714}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNC496MF {ECO:0000313|EMBL:SFI32773.1,
RC ECO:0000313|Proteomes:UP000198714};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FORE01000004; SFI32773.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3HAU1; -.
DR STRING; 1502753.SAMN02799624_00378; -.
DR Proteomes; UP000198714; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SFI32773.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198714};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 4..113
FT /note="Toprim"
FT /evidence="ECO:0000259|SMART:SM00493"
FT DOMAIN 113..203
FT /note="DNA topoisomerase type IA"
FT /evidence="ECO:0000259|SMART:SM00436"
FT DOMAIN 248..550
FT /note="DNA topoisomerase type IA DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00437"
FT REGION 427..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 88894 MW; 378E40BE4D49B46A CRC64;
MGRTIAAVVE PRAQNKRTYL EGERYIITWA IGHLVGLAEP DQYDPKYKRW NEADLPIIPD
RFKLWPNART KDQLKTIGEL SKRCGRLVNA CDAGREGQLI FHLIRQYLKL PQPTDRLWIS
DLTPETIRRG FDGLRSDTDF DDLTRAARAR SEADWLVGMN ASRAFTIRHK ALLSVGRVQT
PVLALLYDRH KEITAFNSET YFIVQAAFTQ DDFGYKGIWQ GDRITKREEA EKLADKVKGK
PGAIVSYTVN ESKEYPYRLY DLTLLQREAN GRYGYPAKKT LDIAQSLYEK HKVITYPRTS
SNYVTEENIP VMGSVLNMLK GTAYADLANG ADRNRVHKGN RAVCNPPKVE DHHAILPTPK
KPGTLSTEEQ NIYDMIVRRF LSHYYPPAVY NNHEVITEIE GETFRTRAKE QLELGWRVVL
EQTEANAAKG KGKGKKKDDD ASAAVEGDED LVETDRPFSV DADRPVRCDD AAAVEKETKP
PKPYTEGTLL KAMESAGKAI EDEELRDAMK QTGLGTPATR AATIERLKQV GYITSAGKRL
DITTKGCTAI ELIRGAGVEL LASPEMTGRW EQRLHQISKG EASDEQFIAK VKQFAEMIVG
KVKQQQQAPA SLFDEPDGGG KRGAKGKGRG AAASARKAGG TAPRAGTRSR GAAAADSAPV
ASRARASARK GTSDSGRMLA APVEAAPASR AKAPAAASRP KTEGRAAKPA PANSEGSAGS
RGTIAPCPRP GCGGQLIEGK RGYGCLRFRE GCSFVIWKEQ QGKHVTPAMA KALAENGVTR
KSTFKLANGT AVSGKWTLTD PAKGTIAFQP AT
//
