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Database: UniProt
Entry: A0A1I3HWS7_9ACTN
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Original site: A0A1I3HWS7_9ACTN 
ID   A0A1I3HWS7_9ACTN        Unreviewed;       429 AA.
AC   A0A1I3HWS7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=hydroxyacid-oxoacid transhydrogenase {ECO:0000256|ARBA:ARBA00013182};
DE            EC=1.1.99.24 {ECO:0000256|ARBA:ARBA00013182};
GN   ORFNames=SAMN05216561_10816 {ECO:0000313|EMBL:SFI40047.1};
OS   Nocardioides psychrotolerans.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1005945 {ECO:0000313|EMBL:SFI40047.1, ECO:0000313|Proteomes:UP000198649};
RN   [1] {ECO:0000313|EMBL:SFI40047.1, ECO:0000313|Proteomes:UP000198649}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.11156 {ECO:0000313|EMBL:SFI40047.1,
RC   ECO:0000313|Proteomes:UP000198649};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-
CC         hydroxyglutarate + acetoacetate; Xref=Rhea:RHEA:23048,
CC         ChEBI:CHEBI:11047, ChEBI:CHEBI:13705, ChEBI:CHEBI:15801,
CC         ChEBI:CHEBI:16810; EC=1.1.99.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00000813};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate +
CC         succinate semialdehyde; Xref=Rhea:RHEA:24734, ChEBI:CHEBI:15801,
CC         ChEBI:CHEBI:16724, ChEBI:CHEBI:16810, ChEBI:CHEBI:57706;
CC         EC=1.1.99.24; Evidence={ECO:0000256|ARBA:ARBA00001110};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. Hydroxyacid-oxoacid transhydrogenase subfamily.
CC       {ECO:0000256|ARBA:ARBA00010005}.
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DR   EMBL; FOQG01000008; SFI40047.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I3HWS7; -.
DR   STRING; 1005945.SAMN05216561_10816; -.
DR   OrthoDB; 323926at2; -.
DR   Proteomes; UP000198649; Unassembled WGS sequence.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0047988; F:hydroxyacid-oxoacid transhydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd08190; HOT; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR042157; HOT.
DR   PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
PE   3: Inferred from homology;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198649};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          22..418
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
SQ   SEQUENCE   429 AA;  44939 MW;  3173ECD333F8F682 CRC64;
     MGPLGYLDRV TETVFTYASP ALKFGSGASA EIGHDLAGWG ARRVLLVTDP GVAATGHPAR
     IAEQMAGFDL DVTTYDGARV EPTDESLDAA IAFARDAGPF DAIVAVGGGS AIDTAKAVNL
     LTTNPGELMD YINAPVGKAR APINPLLPLV AVPTTTGTGS ESTTICVLDV LALKVKTGIS
     HALLRPRLAV VDPSLTLTQP TMVTAASGMD ILCHALESYT ARWYADFDAK RPEQRVPYCG
     ANPVADVWSE KALSMLAASF RAAVRDGSDT VAREQMALAA TFAGLGFGNA GVHIPHANAY
     PIAGRVRTFR PEGYPDDEAI VPHGMAVSLT APEAFRFTFD AAPERHLHAA RLLEPDVPGA
     GPDVLPGVLA RLMRDIGIPN GLGEVGYGEG DVGDLVAGSL QQQRLLATAP KPVTDEDLEA
     VFLGSMEHW
//
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