ID   A0A1I3I3B2_9BURK        Unreviewed;       183 AA.
AC   A0A1I3I3B2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Hypoxanthine phosphoribosyltransferase {ECO:0000313|EMBL:SFI42484.1};
GN   ORFNames=SAMN05192543_10346 {ECO:0000313|EMBL:SFI42484.1};
OS   Paraburkholderia megapolitana.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=420953 {ECO:0000313|EMBL:SFI42484.1, ECO:0000313|Proteomes:UP000199548};
RN   [1] {ECO:0000313|EMBL:SFI42484.1, ECO:0000313|Proteomes:UP000199548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 23650 {ECO:0000313|EMBL:SFI42484.1,
RC   ECO:0000313|Proteomes:UP000199548};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:58115; EC=2.4.2.8;
CC         Evidence={ECO:0000256|ARBA:ARBA00000210};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25426;
CC         Evidence={ECO:0000256|ARBA:ARBA00000210};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=2.4.2.8;
CC         Evidence={ECO:0000256|ARBA:ARBA00001442};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17975;
CC         Evidence={ECO:0000256|ARBA:ARBA00001442};
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DR   EMBL; FOQU01000003; SFI42484.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I3I3B2; -.
DR   STRING; 420953.SAMN05192543_10346; -.
DR   OrthoDB; 9802824at2; -.
DR   Proteomes; UP000199548; Unassembled WGS sequence.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   PANTHER; PTHR43340:SF1; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR43340; HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   4: Predicted;
KW   Glycosyltransferase {ECO:0000313|EMBL:SFI42484.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199548};
KW   Transferase {ECO:0000313|EMBL:SFI42484.1}.
FT   DOMAIN          14..165
FT                   /note="Phosphoribosyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00156"
SQ   SEQUENCE   183 AA;  20319 MW;  E8601B66FC88A0B6 CRC64;
     MNREEALHIF RHSEEIVSAG DVNASISGMA AAIRAEISEE FPLVLSVMGG AAVFTGMLLP
     HLDFPLEFDY IHLTRYRNTT KGGADMQWRV APAESVKDRV VLVLDDILDE GETMAAIRDR
     ILDMGAKRFL SAVLCEKTLT KTKPLHPDFC GFEVPDRYVF GCGMDAKGYW RNLPTIRALT
     EGA
//