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Database: UniProt
Entry: A0A1I3IR31_9BURK
LinkDB: A0A1I3IR31_9BURK
Original site: A0A1I3IR31_9BURK 
ID   A0A1I3IR31_9BURK        Unreviewed;       389 AA.
AC   A0A1I3IR31;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 6.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SAMN05192543_103378 {ECO:0000313|EMBL:SFI50382.1};
OS   Paraburkholderia megapolitana.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=420953 {ECO:0000313|EMBL:SFI50382.1, ECO:0000313|Proteomes:UP000199548};
RN   [1] {ECO:0000313|EMBL:SFI50382.1, ECO:0000313|Proteomes:UP000199548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 23650 {ECO:0000313|EMBL:SFI50382.1,
RC   ECO:0000313|Proteomes:UP000199548};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FOQU01000003; SFI50382.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000199548; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199548};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199548};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       44    340       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   389 AA;  41398 MW;  B5B3B45E73ED818F CRC64;
     MEQFTQMPFV PSRVCAGAVS TAAQLRASLP VTGEAAALVR RTQESLARIL AGHDDRLALI
     VGPCSIHDAN AALDYAARLA RLRGKHTDAL EIVMRVYFEK PRTTVGWKGW INDPMLDGTF
     RIETGLRVAR RLLVDIHALG VPAATEFLDL MTVPYLDDLV SWCAIGARTT ESQTHRQTAS
     GLAAPVGFKN STDGNVRIAI DAVEAARGAH HYLAPSDDGA LEIVATRGNR SAHVVLRGGK
     VPNYDAPSVA SACAELRRAG LPAHVVVDAS HGNSGKRAQA QIGVCEDIAK RLAHGESHVA
     GLMLESHLVE GRQDIGPGAS LVYGQSITDA CLGWSDTVEL VERLADAVRE RRRLTGGLTS
     GLTSGLTSGE LQAAREARSE MHAAQAITH
//
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