ID A0A1I3J5A4_9GAMM Unreviewed; 3882 AA.
AC A0A1I3J5A4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SFI55452.1};
GN ORFNames=SAMN05421680_10292 {ECO:0000313|EMBL:SFI55452.1};
OS Xenorhabdus mauleonii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=351675 {ECO:0000313|EMBL:SFI55452.1, ECO:0000313|Proteomes:UP000198919};
RN [1] {ECO:0000313|Proteomes:UP000198919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17908 {ECO:0000313|Proteomes:UP000198919};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FORG01000002; SFI55452.1; -; Genomic_DNA.
DR STRING; 351675.SAMN05421680_10292; -.
DR OrthoDB; 9757559at2; -.
DR Proteomes; UP000198919; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd17651; A_NRPS_VisG_like; 1.
DR CDD; cd19544; E-C_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1000..1074
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2104..2179
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3204..3278
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3807..3881
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3882 AA; 432073 MW; 65D00875455FE568 CRC64;
MSSNHNRASE ISQAIDNGAS PSCHASPLST IQQAIWLEQA IHPDSSNYNI GFFICIEGKL
NEALFARAFE KAVHYHDALR LQFTDIHGLP SQKIVDTLPA SIVIRDFSSY PDAKAQIKQH
IDASFIRQFH LNGALWRTEL LRVSQTCRYW QFCCHHLIND GTGLFTLLNN VINAYNCLMK
DEPLNWNAFS YLDFVQNERT YLDSQAYSQD LQFWLQRFEN PPSPLLYPVH ADKTARQGKA
ENIFWRLDQT MAQRIETIFA RQGLPFLYFM YAVIACYFVR TTGTDEIVIG IPVHNRKNAR
QKRTLGVFVS VIPIRVTVSP EDTLRDVMQK AEAEFNQSYK HQRVPMAEVS RKTHIKQKTG
RANLFDIALS IELFNADLHI EGEDAQVKYF ELYRGIPPYP LAISVKQYAL GLGDDNPPIA
IEFNFSTDYL SVEEIAALQS RLAVLLDAAL ASPDTPIADL PILPEDERQK VLVDFRAPQI
DFPQNAVIHQ LFETQVKSTP DAIAVVFEDQ SLSYDALNRC ANRLAHQLIA LGVRPDDRVA
ICAERSLDIV IGLLGILKAG GAYVPLDPTY PAERLAYMLN DSAPVALLIQ PATAKMLDNQ
LSISHIPAIM LEGGKPDNKN QPALDEKSAE NPDSQALGLT SHNLAYVIYT SGSTGQPKGV
MVEHYGLCNL ITTQQKILSL TPGSRLLQFV SNSFDVYIWE CCMALLAGSQ LYLAKRADIL
PGATLSHYLE THAITHVFLS PTVLAAMDSI PDTVQVLITG SEVCPLIQVK RWAHGRQMFN
GYGPTETTIC VTLYQCNDQD KNAPPIGRPI ANTQIYILDT NGQPVPIGST GEIYIGGVGV
TRGYLNLPEL TQSVFLPDPF SIATGARMYK TGDLARWLPD GNIEYISRND FQIKLRGYRI
ELGEIENHLT QCQGVREAVV IDRKDNTGQK RLVAYLLAKP DTKLVPTQLR QQLTQKLADY
MIPSAFVTLD TFPQTPNGKL DRQALPEPDQ SAIVTYGYDA PVSPAEIALA QSWQALLGLE
NVSRHDHFFE LGGHSLVAVR LTEQLYHLGW RLDIHSVFAA PLLAEMAKSM VIVQDGTTSF
TVPPNLIPAN CTAITPDMLT LISLTQNEID AITATVPGGA ANIQDIYPLA PLQEGILFHY
LLQTQGDTYL LRTLFAFDTR KRLDDFLAAL QQVINRHDIL RTGICWQGLT HPVQVVWRQA
FLPINQFIPD SKEDVLSQLL LHTDPIRHRV DVSQAPLFSA DIAYELHQDE WLLSLSFHHL
VSDHMTLELI ITEINQQLHS RARHHHAHAE NSPEALFLSE ALPYRNFVAQ SLSVPAEIHE
AYFREELADV EISTAPFGVL GVLDVHSGGR QVTEASRFME PALANVIREQ ARRQGISPTV
LFHVAWAQVL AHTSGQNDVV FGTVLLGRMQ GNAGIEKIMG LFINTLPVRI PLAGNSVQEI
LQATHHRLIK LLEHEQAPLV LAQRCSSVPP SQPLFSSLLN YRHTTPGAIH TPLEGVRLLE
VRERTNYPIM LCVDDLGEDF SLIAQAVSGI DAKRLIDYMI TALTGLVTAL DSEPQKPILN
ISILPATERR QLLVDFNATQ TDFPHDALIH QLVEAQVART PNATALVYGK QFFSYDELNQ
RANRLAHHLV AQGMHPDERV AICVERNLEM VVGLLAILKA GGAYVPLDFT YPAERLAYML
EDSAPVIVLT QASLAGKLTH HVPTVLIDNF FADRESPIEP QSKNNPDAKR LGLTSHHLAY
VIYTSGSTGL PKGVAITHRN TVNFLTWAQR TFDQKALAHT LFATSFSFDL AVYECFAPLI
SGGTVHIVSD ALSLIAAERP STEALAEKSG SISLINTVPS AIAQLLETDA IPPTVRAVNL
AGEALRPHIV EQLFTNSSVQ HVCNLYGPSE TTTYSTWACM DRATGFVNHI GRPIANTRVY
ILDTHGQPTP LGVAGEIYIA GAGVARGYLN HPELTTGRFL IDPFSSELNA RMYKTGDLGR
WLPDGNIEYL GRNDFQVKLR GFRIEPEEIE ARLAQCQGVR EAIVILREDE PNQKRLVAYL
LAEPDTELVP AELHQQLARH LASYMIPCAF VILEAFPLTP NGKLNRKALP VPDQAAIVTH
SYEAPAGKLE IALAEIWQTL LGLEKVGRHD HFFELGGHSL LAVQLIARVR QTLSLELSLP
QFFANPIFAD LATALTKAPS VAQSAIPVAD RHQPLPLAFA QQRLWFLACL NPTACLAYQI
PNVLRFNGQL NHAAFADALN RLVSRHEGLR TRFLLIDGQP CQHIDAVDTG FALSYHDLRS
SDPTVSTATA HRKHLEELVA LEAKTPFDFT NEPSIRGQLL QLADEEHVFI LTQHHIITDG
WSIGILIREM GILYRAALEK QNSPLPPLPI QYADYAVWQQ EWLRDDRITA QQNFWREQLR
DAPALLALPT DRPRPPEQRY TGGYVPIHLN IGTLDALQSL GQRQDTTLFM TLLAAWGAVL
ARLSGQDDIV IGIPVANRPH RDLEGVIGFF VNTLPLRIKL ENCRTVAQLL SHVREQSLAA
YAHQDLPFEQ LVENLQPERS LSYSPIFQTM LALNNIPTQS FELPDLTVSL MEQTRHYANF
DLTLSLTETN KGLEGYLEYA LDLFDRTTIE RIAGHFNNVL AAMAADETRD IAHLPMLSIA
ERRQLLFDFN APQVNFSPDA LIHSYFEAQV QRTPNAAAVV FEDQSLSYHE LNCRANQLAH
SLIAFGVRPA DRVAICVERS LDMIIGLLGI LKAGAGYIPL DPAYPTERQI YQLSDSKPVI
LLTQQHLQQN LQQGTSSIQG LSIWLLDDET HQRRTEKQPE HNPDSKRLGL QPHHLAYIIY
TSGSTGHPKG VMVEHRNVVS LIHAQRQVSH PCPEDRILQF VTIAFDISVS DIFPTLASGA
TLVLRPPHIK VPNNTFIDFL REQAITILNI PTAFWHHWVQ EMKSGSCGFS PCLRTVIVGG
DKVERRYLTD WLSLPETHSC RWFNAYGPTE ITVTASTLLV DDSNISTIND NIPIGRPLSN
TCIYILDKFG QPVPIGVCGE IYIGGMGVTR GYSNQPELTA ERFIADPFSK HPNARMYKTG
DLARWRLDGN IEYLGRNDFQ VKIRGFRIEL GEIEARLLQC CGVREAIVLA RQDFSGHAVS
AKKVVVSKNI EGEKRLVAYL LAEPNVKLTP AKLRQQLAQH LAEYMLPSAF VILDAFPLAP
NGKIDRQALP MPDQTALVTR AYAPPTGSTE MTLAEIWQAL LGLDKVSRYD HFFELGGHSL
MIVNLIERLR NQGLVLDIRT VFASPVLADM AKAVRARNEN PRLASVPPNL IPDGCNKITP
DMLPLVALTQ CEIDAIAATV PGGAANIQDI YPLAPLQEGM LFHHLLQTQG DIYLLHLMLT
FDTRERLDAF LAAFQQTIDR HDILRTAICW QNLSQPVQVV WRQASLRINA FVPDNVPDNM
ADGDKDVQSQ LKAYTDPRCH RLDVTQAPLF STDIAYDPHQ GKWLLALCSH HIINDHVSLD
LITTEIHQLL YPHSGQLSLG DSHSTESPSA PQFSPLLPYR DFIGQSLRVP ASEHKAYFHE
VLSDVDTPTA PFGILDIYSS DKAVTEAIKL LNASLSREIR KQARRHGVSP GVLFHVAWAQ
VVAKLSGRND VVFGTVLLGR MQSNADITRT PGLFINTLPI RIRLGGNSVQ TTVQATYRSL
TQLLEHEQAS LALAQSCSGV KPPLPLFTAL LNYRHSPSDT TRNTWEGIEL LTARERTNYP
LYMAVDDLGK GFRLAAQTVQ HIEPERVLAH MTIALTGLVQ ALETEPESPI ADIPVLSITE
HRQLQIDFPQ EPFISAQSMG KSHGHEDPIG DIEASLVKIW QQLLKQDQIS RHDNFFTLGG
NSLLAIQLLA RMHEQGMQIP LAALFIHPTL CELAEIVAGS FS
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