ID A0A1I3KSG9_9FLAO Unreviewed; 586 AA.
AC A0A1I3KSG9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Phenylalanine-4-hydroxylase {ECO:0000313|EMBL:SFI75459.1};
GN ORFNames=SAMN05443431_102102 {ECO:0000313|EMBL:SFI75459.1};
OS Olleya namhaensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1144750 {ECO:0000313|EMBL:SFI75459.1, ECO:0000313|Proteomes:UP000199559};
RN [1] {ECO:0000313|Proteomes:UP000199559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28881 {ECO:0000313|Proteomes:UP000199559};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; FORM01000002; SFI75459.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3KSG9; -.
DR STRING; 1144750.SAMN05443431_102102; -.
DR Proteomes; UP000199559; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.58.690; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199559}.
FT DOMAIN 1..345
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 132
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 137
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 222
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 586 AA; 65560 MW; BC12B657249BB0FE CRC64;
MEFKNIESNP ILDRLPKHLR QFIKPQDYED YSAIDQAVWR YAMRKNVDYL SQVAHSTYIE
GLQQTGISVD AIPNMYGMNR ILKAIGWAAV AVDGFIPPNA FMEFQAYNVL VIASDIRQLE
HIEYTPAPDI IHEGAGHAPI IANPEYAEYL RRFGEIGCKA ISSAKDYELY EAVRHLSIIK
EAPNTPQDQI DLAEKAVEDL QNNMGEPSEM ALIRNLHWWT VEYGLIGTIE NPKIYGAGLL
SSIGESAWCM TDKVKKLPYT IDSTFQNFDI TKPQPQLYVT PDFAHLSLVL ESFANTMALR
TGGPSAIKKL IHSQALGTIE LSTGLQISGV FTNMIEHNGK VSYIQTTGKT ALANRDKELV
GHSTLEHADG FGSPIGKLKG INLAIEDMSP RDLRAYDIYE GETVTLEFEN DIIVTGEIIT
GTRNLQGKII LISFKNCTVT HKDTILFDPT WGLYDMAVGK EVLSGYSGPA DLHSFDLITH
KVSSTTIHVK HSAEKLELID LYKQVRDYRE GTNPTISRTK VLEQLVNRFP MDWLLPIELF
ELAKKGNENE LCNSILGHLE TIKQNRPEVG HLIDDGVKIA SQEIAV
//
