ID A0A1I3LN16_9FLAO Unreviewed; 1112 AA.
AC A0A1I3LN16;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN05443431_102495 {ECO:0000313|EMBL:SFI86092.1};
OS Olleya namhaensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1144750 {ECO:0000313|EMBL:SFI86092.1, ECO:0000313|Proteomes:UP000199559};
RN [1] {ECO:0000313|Proteomes:UP000199559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28881 {ECO:0000313|Proteomes:UP000199559};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FORM01000002; SFI86092.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3LN16; -.
DR STRING; 1144750.SAMN05443431_102495; -.
DR Proteomes; UP000199559; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000199559}.
FT DOMAIN 569..730
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 739..905
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1112 AA; 127460 MW; FF8A0644874FE20F CRC64;
MSKTLISQTY LQSLQLQKLQ TAISQTQSKT HLKGLVGSSL SYIITQTFKN TQLPFLLIFN
DKEEAAFYLN DLEQLINKTD VLFYPGSYRR PYQIEETDNA NVLLRAEVLN RINSRKKPAI
IVTYPDALFE KVVTRKELER NTLKINVNDS LSIDFVNEIL FDYKFKRVDF VTEPGEFSVR
GGIVDVFSFS HDEPYRIEFF GDEVDSIRTF DVETQLSTEQ IKKISVIPNV ANKLMDESRQ
SFLNYIAQKT VVFGKNFDLT FDRVDDFFDK AITAFVKLNQ DIKHAKPSEL FCNAAELKKQ
LLDFTIVEFG SSPVFNPTET IVHNTSPQPT FNKQFNLLID NLNSNHNNDY TNYIACVSEQ
QAKRFHDIFD DVDQNVHYQT VTLSLYQGFV DHDNKIVVYT DHQIFERYHK FHVKNGYAKK
QAITLKDLTN LDIGDYVTHI DHGIGKFGGL QKIDVEGKKQ EAIKLVYGER DVLYLSIHSL
HKITKFNGKD GKPPKVYKLG SKAWKVLKEK TKSRVKHVAF NLIKLYAKRK LEKGYQYKPD
SYLQHELEAS FLYEDTPDQI TATADIKVDM ESERPMDRLI CGDVGFGKTE VAIRAAFKAV
DNGKQVAVLV PTTILAFQHH KTFTERLKDL PVTVDYVNRF RTAKQKKETL EKLEKGHVDI
IIGTHQLASK NVKFKDLGLL IVDEEQKFGV AVKEKLKTLK DNVDVLTLTA TPIPRTLQFS
LMAARDLSVI TTPPPNRYPI ESNVIRFTEE AIRDAVSYEI ERGGQIFFIH NRIENIKEVA
GMIQRLVPDA KIGIGHGQLE GKKLESLMLG FMDGEFDVLV STTIIESGLD VPNANTIFIN
NANNFGLSDL HQMRGRVGRS NKKAFCYFIT PEYSAMTDDA RKRIQALEQF TELGSGFNIA
MKDLEIRGAG DLLGGEQSGF INEIGFDTYQ KILNEAIEEL KENEFKDLYN EPLENKEYVK
DITIDTDFEL LFPDDYVNNI AERLNLYTQL NNFKTEAELA EFEKQLLDRF GELPIQVIDL
IDSVRIKWIA TKLGMEKVIM KQGKLISYFI NDQQSSFYQS PNFTKLLKYV QTHPKSCKMK
EKQTRNGLRL LLTFDNIKSV KKALNALKPI LE
//