ID A0A1I3MH02_9PSED Unreviewed; 984 AA.
AC A0A1I3MH02;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05216206_3278 {ECO:0000313|EMBL:SFI96050.1};
OS Pseudomonas guineae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=425504 {ECO:0000313|EMBL:SFI96050.1, ECO:0000313|Proteomes:UP000243606};
RN [1] {ECO:0000313|Proteomes:UP000243606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 24016 {ECO:0000313|Proteomes:UP000243606};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000256|ARBA:ARBA00006434}.
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DR EMBL; FOQL01000004; SFI96050.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3MH02; -.
DR STRING; 425504.SAMN05216206_3278; -.
DR OrthoDB; 9815750at2; -.
DR Proteomes; UP000243606; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd10322; SLC5sbd; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.20.1730.10; Sodium/glucose cotransporter; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:SFI96050.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000243606};
KW Transferase {ECO:0000313|EMBL:SFI96050.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 763..977
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 984 AA; 108333 MW; BE88A14B34683788 CRC64;
MLTSFSLSQL ILISAAYLLI LFGVAWISEH GLIPRWIIRH PLTYTLSLGV YASAWAFYGT
VGLAYQYGYG FLASYLGVSG AFLLAPVLLY PILKITRTYQ LSSLADLFAF RFRSTWAGAL
TTVFMLIGVL PLLALQIQAV ADSIGILTRE PVQERVALAY CGLIILFTIL FGARHIATRE
KHEGLVFAIA FESVVKLVAI SIIGLYALYG VFDGPQDLQS WLVQNQASLS NLHTPLQEGP
WRTLLLVFFA SAIVMPHMYH MTFTENLNPR AMVSASWGLP LFLLLMSLAV PLILWAGLKL
GATTNPEYFT LGVGIAVNSQ TLALIAYVGG LSASSGLIIV TTLALSGMVL NHVVLPLYQP
PAEGNIYRWL KWTRRALILL VIMAGYGFYL LLGAEQDLAN LGIVAFVATL QFLPGVLSVL
YWPTANRKGF IAGLLAGVGV WVVSMLLPML GNLQGLYLPW FNVIYVLDDS SWHMAAIASL
AANVLVFTLV SLFTEASQEE KSAAEACAVD NVRRPQRREL LANSPQEFAA QLAKPLGAKT
AQHEVEQALR DLHLPFDEAR PYALRRLRDR IEANLSGLMG PSVAQDIVET FLPYKAGSET
YVSEDIHFIE NRLEDYHSRL TGLAAELDTL RRYHRQTLQE LPMGVCSLAK DQEILMWNKA
MEELTEIPAQ RVVGSRLSAL GEPWRGLLQN FIELPDEHLH KQSLALDGQT RWLNLHKAAI
DEPLAPGNSG LVLLVEDLTE TQMLEDKLVH SERLASIGRL AAGVAHEIGN PITGIACLAQ
NLREEREGDS ELTEISAQII EQTKRVSRIV QSLMSFAHSG SHQNSEEPVC LAQVAQDAIA
LLALNRQSVD VQFFNLCDSD HWVIGDPQRL AQVLINLLSN ARDASPPSSA IRIKSEAFEH
TVDLIVEDEG TGIPKAIIDR LFEPFFTTKE VGKGTGLGLA LVYSIVEEHY GQITIDSPAD
PELQRGTRIR VSLPRHVEAT SLAT
//
