ID A0A1I3PKX3_9BACL Unreviewed; 694 AA.
AC A0A1I3PKX3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Ribonucleoside-diphosphate reductase {ECO:0000256|ARBA:ARBA00012274, ECO:0000256|RuleBase:RU003410};
DE EC=1.17.4.1 {ECO:0000256|ARBA:ARBA00012274, ECO:0000256|RuleBase:RU003410};
GN ORFNames=SAMN05518846_102411 {ECO:0000313|EMBL:SFJ22188.1};
OS Brevibacillus centrosporus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=54910 {ECO:0000313|EMBL:SFJ22188.1, ECO:0000313|Proteomes:UP000198915};
RN [1] {ECO:0000313|Proteomes:UP000198915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK042 {ECO:0000313|Proteomes:UP000198915};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Provides the precursors necessary for DNA synthesis.
CC Catalyzes the biosynthesis of deoxyribonucleotides from the
CC corresponding ribonucleotides. {ECO:0000256|RuleBase:RU003410}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-
CC diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-
CC diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000206,
CC ECO:0000256|RuleBase:RU003410};
CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC chain family. {ECO:0000256|ARBA:ARBA00010406,
CC ECO:0000256|RuleBase:RU003410}.
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DR EMBL; FORT01000002; SFJ22188.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3PKX3; -.
DR STRING; 1884381.SAMN05518846_102411; -.
DR UniPathway; UPA00326; -.
DR Proteomes; UP000198915; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd01679; RNR_I; 1.
DR Gene3D; 1.10.1650.20; -; 1.
DR Gene3D; 3.20.70.20; -; 1.
DR InterPro; IPR013346; NrdE_NrdA_C.
DR InterPro; IPR026459; RNR_1b_NrdE.
DR InterPro; IPR000788; RNR_lg_C.
DR InterPro; IPR013509; RNR_lsu_N.
DR InterPro; IPR013554; RNR_N.
DR InterPro; IPR008926; RNR_R1-su_N.
DR InterPro; IPR039718; Rrm1.
DR NCBIfam; TIGR02506; NrdE_NrdA; 1.
DR NCBIfam; TIGR04170; RNR_1b_NrdE; 1.
DR PANTHER; PTHR11573; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; 1.
DR PANTHER; PTHR11573:SF6; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT; 1.
DR Pfam; PF02867; Ribonuc_red_lgC; 1.
DR Pfam; PF00317; Ribonuc_red_lgN; 1.
DR Pfam; PF08343; RNR_N; 1.
DR PRINTS; PR01183; RIBORDTASEM1.
DR SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR SUPFAM; SSF48168; R1 subunit of ribonucleotide reductase, N-terminal domain; 1.
DR PROSITE; PS00089; RIBORED_LARGE; 1.
PE 3: Inferred from homology;
KW Deoxyribonucleotide synthesis {ECO:0000256|ARBA:ARBA00023116,
KW ECO:0000256|RuleBase:RU003410};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003410};
KW Reference proteome {ECO:0000313|Proteomes:UP000198915}.
FT DOMAIN 552..574
FT /note="Ribonucleotide reductase large subunit"
FT /evidence="ECO:0000259|PROSITE:PS00089"
SQ SEQUENCE 694 AA; 79691 MW; 20FC693A258AAB32 CRC64;
MRHIELNNEL MQRGEDGFYQ LEKDREAVEV FLEEVQAKTL TFNSVGERMD YLIQNDYYEN
VYERYTEEQV EEVFRLAKDA SFQFASYMAV SKFYKDYALK TDDKSMYLEQ YPDRVAIVAL
SLAQGDFDRA KRLTVSMMDQ RLQPATPTFL NAGKSRRGEM VSCFLLEMDD SLNSINYILG
TCMQLSKIGG GVAVNLSKLR GRGEPIKGVE GAAKGIMPVL KLLEDAFSYA DQMGQRKGSG
AAYYNIFGWD INEFLDCKKI NADEKSRIKT LSIGLIVPNM FYKLAEENKP LTIFAPYSVY
KEYGQHLDDM NMDEMYEELL ANDNIKKKTI MSARDMLTKI AMIQLESGYP YIMNKTNANK
NHALKDIGSV KMSNLCTEIF QLQDTSTINN YGEMDIIRRD ISCNLASLNI VNVMEQKKIR
ESVHEGIEAI TSVSDMTAVE NAPGVQKANR ELHSVGLGAM NLHGYLAKNK IAYESEEAKD
FARTFFMMMN FYSLEMSMEI AKERKTTFLG FEQSEYAKGT YFSKYEETDY RPRTEKVKQL
FADMYIPTTE DWAQLKEKVQ TYGLYHAYRL AIAPTQSISY IQNATSSVMP IVEHIETRTY
ANSTTYYPMP YLSQENYFFY KSAYVIDQFK VIDLIAEIQE HVDQGISTVL HVNSNVSTRE
LARYYIYAAK KGLKSLYYTR TKHLTVEECI SCAV
//