ID A0A1I3RSM9_9SPHI Unreviewed; 1520 AA.
AC A0A1I3RSM9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Hydrophobic/amphiphilic exporter-1, HAE1 family {ECO:0000313|EMBL:SFJ49553.1};
GN ORFNames=SAMN05444682_110124 {ECO:0000313|EMBL:SFJ49553.1};
OS Parapedobacter indicus.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Parapedobacter.
OX NCBI_TaxID=1477437 {ECO:0000313|EMBL:SFJ49553.1, ECO:0000313|Proteomes:UP000198670};
RN [1] {ECO:0000313|EMBL:SFJ49553.1, ECO:0000313|Proteomes:UP000198670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RK1 {ECO:0000313|EMBL:SFJ49553.1,
RC ECO:0000313|Proteomes:UP000198670};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Cell membrane
CC {ECO:0000256|RuleBase:RU362097}; Lipid-anchor
CC {ECO:0000256|RuleBase:RU362097}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613, ECO:0000256|RuleBase:RU362097}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; FOQO01000010; SFJ49553.1; -; Genomic_DNA.
DR STRING; 1477437.SAMN05444682_110124; -.
DR OrthoDB; 9758234at2; -.
DR Proteomes; UP000198670; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR Gene3D; 2.20.200.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR NCBIfam; TIGR01845; outer_NodT; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|RuleBase:RU362097};
KW Membrane {ECO:0000256|RuleBase:RU362097, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|RuleBase:RU362097};
KW Reference proteome {ECO:0000313|Proteomes:UP000198670};
KW Transmembrane {ECO:0000256|RuleBase:RU362097, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|RuleBase:RU362097};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1003..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1520 AA; 166738 MW; D6B5C86B3D5A2AB9 CRC64;
MLETFIKRPV LSLVISLLIT LLGLLSLFTL PVTQFPDIVP PSVVVTANYT GANAEVCTDA
VAIPLERAIN GVAGMTYMTS VSTNNGTTLI QVFFKVGTDP DIAAVNVQNR VTTVLDELPE
EVIKAGVTTE KEVNSMLMYL NVFSDDPTAD ERFIYNFTDI NILKELKRIE GVGFAQIMGM
RDYAMRVWLK PDRLTAYDIS SEEVIAALRA QNVEAAPGQT GIGSDQRINM QQYVLRYPGK
FSEPEQYRNI PIRANADGSV LRVGDIAEVE FGSLDYEMES RTDGRPSASI MMKQLPGSNA
QEVIENVKQR MAELQETSFP PGMKYTVSYD VSRFLDASIN EVIRTLIEAF LLVFLVVFIF
LQDFRSTLIP ALAVPVCLIG ALFFMQLLGF SINLLTLFAL VLAIGIVVDN AIVVVEAVHV
KMEEDHLPPM EATLAAMKEI GGAVVAITLV MSAVFVPVAF LSGPVGIFYR QFSLTLAAAI
VISGINALTL TPALCALFLR SPHGKPPSKG WLPSFFKRFN RWYNGISSRY AGLIGKIAGR
RVVTLGLLAG FFVATWGVNS ILPSGFIPTE DQGMIYVNVT TPPGATVDRT IAVLNQIDSI
SRQHEAVETV STLAGYSIVT EVSGASYGMG MINLKAWENR RESVADVIDW LEDNTGHLMD
ASIEYFPPPT VPGFGNSSGF ELRLLDRSGA DNLQHTADVL ETFMTALEET PEVGNTFSTF
DPRFPQYLVN VDHDMAAKRG ISVENAMTTL QTLMGSFYAT NFIRFGQMYK VMVQAGPGYR
EKPEDVLKLH VKNNSGEMVP FSAFITMERV YGPEQVTRYN MFSSALISGD AAPGFSSGQV
IDAVERVAAA TLPQGYAIEW SGMTREQILS GNQAIYVFAL CLLFVYLILA AQYESFLLPL
PVILSLPAGV FGAFLFLKLL GLENNIYAQV ALVMLIGLLG KNAILIVEYA ILRYKQGATQ
LQAAIEGSVA RLRPILMTSF AFIAGLIPLA MASGAGALGN RSIGTTAVGG MIVGTLVGVI
VIPGLYVLFT AVRRNKKRKA IKAGTAGLLM ITAIGLLSGC TTVKSLPDPQ HRVLPETYAG
NTDTLNTAHQ RWRSFFNDPN LIALIDTALT NHPDMSAALH QIEIAQANLR LRKSAFFPSV
DALAEAGLRR YGFYTMDGIG NYDTNFSENL KDDEKLPDPL PDYFVGLRTT WEIDLWGKLR
NRKRAAYQRF LSSYEGRHLV QTSLIEEVAT TYYDLLALDN ELAILRKNIN LQKNALDIIN
VQKAAGRADE LGVQQFIAMV HHAQGKEQEV RQQISAAEAH LNFLLGRFKG GIPRDTTLWM
TSAFTDSIHV GVPTHFLALR PDIRQARLEL AASGAEQLAA KAEFLPSLVL SPYVGLQAFD
IDKLLLAPTS VAYGLVGGLT APIFNQRTIR TAYETAKATY GIAFHDYERA VLKAWEEVQR
TMTAQKYINR RTDHNLQEVA SLQKAVDAAH ELFKAGRASY LDIITAQRAA LDAELNLVST
RREKAINKLS LYKALGGGWQ
//
