ID   A0A1I3UHH9_9BACL        Unreviewed;       465 AA.
AC   A0A1I3UHH9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN   ORFNames=SAMN05421852_1245 {ECO:0000313|EMBL:SFJ81227.1};
OS   Thermoflavimicrobium dichotomicum.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
OC   Thermoflavimicrobium.
OX   NCBI_TaxID=46223 {ECO:0000313|EMBL:SFJ81227.1, ECO:0000313|Proteomes:UP000199545};
RN   [1] {ECO:0000313|EMBL:SFJ81227.1, ECO:0000313|Proteomes:UP000199545}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44778 {ECO:0000313|EMBL:SFJ81227.1,
RC   ECO:0000313|Proteomes:UP000199545};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR   EMBL; FORR01000024; SFJ81227.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I3UHH9; -.
DR   STRING; 46223.SAMN05421852_1245; -.
DR   OrthoDB; 9780160at2; -.
DR   Proteomes; UP000199545; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13137; MATE_NorM_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199545};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        70..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        143..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        402..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   465 AA;  50329 MW;  BB79BB5C2C5E7574 CRC64;
     MPSTSSFDNL SEVQNKSLLE KGRIVLTLAW PAIVENILQT LVGFVDTLFV SELGLVEVSA
     VGITQTILQV YFAVFMAIGV GSTSLIARAI GANNIKEAQK VAKQSVLLSS WIGILFGLIT
     LFFAEPILRL MGAEPAVLQQ GTIYFRIVAV PSIFISLMFG LGSLLRGVGD TVSPMKAGFW
     MNGIHILLDY VLIFGLGPLP GFGIVGAAVA TVVSRVVGVA ILWIQLRKSE TNIGKGWSRG
     WKADRSVLRS MIQISTPAAI ERLIMRVGQV FYFGLILSLG TYTFAAHQIA GNIEAWSYLP
     GYGFAVAAAT LVGQQLGAGR PKDAFSYGWI SAGLCAVIMG FLGVFEFFGG EWAAHYFTRD
     ASVIQQVGLA LKIDAFKEIP LAIVLVLTGA LNGAGDTKWP MISTAIGIWI VRVAGVYLLG
     IQLEWGLVGI WLAILLDNLW RAVFLGWRFH SRKWSQTMVK ADFSS
//