ID   A0A1I3VP07_9BURK        Unreviewed;       294 AA.
AC   A0A1I3VP07;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:SFJ95987.1};
GN   ORFNames=SAMN05192543_11419 {ECO:0000313|EMBL:SFJ95987.1};
OS   Paraburkholderia megapolitana.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=420953 {ECO:0000313|EMBL:SFJ95987.1, ECO:0000313|Proteomes:UP000199548};
RN   [1] {ECO:0000313|EMBL:SFJ95987.1, ECO:0000313|Proteomes:UP000199548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 23650 {ECO:0000313|EMBL:SFJ95987.1,
RC   ECO:0000313|Proteomes:UP000199548};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; FOQU01000014; SFJ95987.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I3VP07; -.
DR   STRING; 420953.SAMN05192543_11419; -.
DR   OrthoDB; 9777604at2; -.
DR   Proteomes; UP000199548; Unassembled WGS sequence.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006398; Tartro_sem_red.
DR   NCBIfam; TIGR01505; tartro_sem_red; 1.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199548}.
FT   DOMAIN          3..162
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          165..285
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        171
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   294 AA;  30345 MW;  D2469FF7FC73AE8F CRC64;
     MAKIGFIGLG IMGAPMARNL QAGGHALFVY KRNGALPTEL ADGGATSCSS PKEVAQQADI
     VITMLPDTPD VEAVLFGTDG IAHGLSKGKT VIDMSSIAPL QTKAFAEKIA ALGCDYLDAP
     VSGGEVGAKA ASLTIMVGGS DAAFARVKPL FELMGKNITL VGDVGAGQTC KVANQIIVAL
     TIEAVGEALL FASKAGADPA RVREALMGGF ASSRILEVHG ERMIKRTFNP GFRIELHRKD
     LGLALEGAKA LGVPLPNTAT CQQLFTLCSA HDAGQLDHSA LVKALEIMAN HTVA
//