ID A0A1I3W4N8_9BURK Unreviewed; 1958 AA.
AC A0A1I3W4N8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=SAMN05192543_11640 {ECO:0000313|EMBL:SFK02604.1};
OS Paraburkholderia megapolitana.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=420953 {ECO:0000313|EMBL:SFK02604.1, ECO:0000313|Proteomes:UP000199548};
RN [1] {ECO:0000313|EMBL:SFK02604.1, ECO:0000313|Proteomes:UP000199548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 23650 {ECO:0000313|EMBL:SFK02604.1,
RC ECO:0000313|Proteomes:UP000199548};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; FOQU01000016; SFK02604.1; -; Genomic_DNA.
DR STRING; 420953.SAMN05192543_11640; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000199548; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 3.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000199548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 370..614
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1013..1535
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1332..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1958 AA; 213013 MW; 93B46F1EE28440FE CRC64;
MSSHGTIRIR GARQHNLKNL DLDLHTGEMT VVTGPSGSGK SSLVFDTLYA EGQRRYVETF
SAYARQFLDR MDRPQVDRVD GVPPAIAIDQ TNPVRSSRST VGTMTELNDH LKLLYARAAE
LFDRNNAQAV RHDTPETIYA ELVARAAADD PRLVVTFPVE LPESASDAEI EQWLSASGYT
RVQAQREVAS PTGTRKVLDV VADRFRLGNT DKVRAVEAIE ASLKRGAGRV SVYVLPADSA
ARTPDAEPQI WRFSTGLHNP DSDLRYADPQ PALFSFNSAY GACETCRGFG RVIGVDLGLV
IPDARKTLRG GAVKPMQTPA WKECQDDLMR YAAKADIRRD TPWAELTDAE RHWVINGSPD
WNGKWQSHWY GVKRFFEYLE SKAYKMHIRV LLSKYRSYTS CETCGGARLK TESLLWRLGT
KPNADAVLEP TRRFLPRGVE WSRKQLEALP GLTVHDVMLL PIERIRRFFD DIALPSALLD
DALKLLLAEV RTRLKYLCDV GLGYLTLDRQ SRTLSGGEVQ RINLTTALGT SLTKTLFVLD
EPSIGLHPRD LNRIVEAMHR LRDAGNTLVV VEHDPSVMLA ADRLIDMGPG PGERGGTIIY
DGTPTGIRSV TTLTGDYLSG RRHVADAAHW SRREVTADTP RIVLEGASEH NLRDVTVEIP
LQRLVCVTGV SGSGKSTLLQ DVLHPALARH FGNPTESPGA YRNLSGAEYL SDVVFVDQSP
IGKTARSNPA SYVGAFDEIR KLFTKAPLAQ QRGYGAGMFS FNSGDGRCPT CGGSGFEHIE
MQFLSDVYLR CPDCDGRRYR AEVLEVKIER GAPARALSVA DVLELTVSEA IAFFADDAEV
LRVLQPIVDV GLEYVKLGQP VPTLSGGEAQ RLKLAGFLAE TAQPRTTRTA KPAVAGRLFM
FDEPTTGLHF DDIAKLMRAF GKLLAGGHSL IVIEHNLDVI RAADWLIDLG PEGGDGGGLV
LCAGTPDDVK QCAASHTGAA LIQYDRAVGA AVEATDGVPL QTSLAAARAR RAIEGDDVVR
IVNAREHNLK ALDVDIPHGK FNVITGVSGS GKSTLAFDIL FHEGQRRYLE SLNAYARSIV
QPAGRPEVDA VYGIPPTVAI EQRLSRGGRK STVATTSEVW HFLRLLYVKL GIQHCIHDGT
PVTAQSVESI AAQLLRDHRG QHVGLLAPLV VNRKGVYTDL AKWAKARGNT HLRVDGEFVP
VDPWPKLDRF REHTIELPVA DLVVSADDEA ELRRRLDETL EIGKGVMHLL APLDGLQDAL
MKGRVTAGVG DVKVLSTKRA CPVCGTSYPE LDPRMFSYNS KHGWCTTCVG TGLKLTREQR
AAYDDTVLIE DGRGREQSLP SEEQEPEGVV DEPCPDCNGT RLNPVAGAVT FSSKAIVDVA
RWTVTDTRRW IDGLKLTGRD AGIARDVVSE IGSRLQFLEE VGLGYLSLDR AAPSLSGGEA
QRIRLAAQLG SNLQGVCYVL DEPTIGLHPR DNQILLNALR KLGDKGNTLV VVEHDEDTIR
RADHIIDIGP GAGKRGGALV AQGSVADLAK QPTSLTGQFL ARPIAHPLQP RRTVEPARKN
KPAVPEQWLT VHGAKLHNLR NVTVGIPLAR LVAVTGVSGS GKSTLARDVL MTNLLDAVGR
SVLSSPATRR ARNAVQSAPA ANRRSSVLAR SAPRPAYTVN HVWQGCDSIT GWEAIDRVLE
VDQTPIGKTP RSCPATYIGV WDTIRKLFAD TLEARARGYT ASRFSFNTGD GRCPACEGQG
VRTIGMSFLP DVKVPCDVCH GQRFNPETLA VSWRGKNIGD VLTMEIDEAV EFFAPMSNIA
HPLQLMKDVG LGYLTLGQPS PTLSGGEAQR IKLVTELSKV RDDITRRGQK APHTLYVLDE
PTVGLHMADV AKLIRVLHRL ADAGHSVVVI EHDLDVIAEA DWIIDLGPEG GASGGTIVAA
AAPEQLVRVA RSHTGEALAP VLARSGDQPA VEAQVSVG
//
