ID   A0A1I3XV65_9BACL        Unreviewed;       253 AA.
AC   A0A1I3XV65;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=L-ascorbate metabolism protein UlaG, beta-lactamase superfamily {ECO:0000313|EMBL:SFK23169.1};
GN   ORFNames=SAMN05518846_11086 {ECO:0000313|EMBL:SFK23169.1};
OS   Brevibacillus centrosporus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=54910 {ECO:0000313|EMBL:SFK23169.1, ECO:0000313|Proteomes:UP000198915};
RN   [1] {ECO:0000313|Proteomes:UP000198915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK042 {ECO:0000313|Proteomes:UP000198915};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Counteracts the endogenous Pycsar antiviral defense system.
CC       Phosphodiesterase that enables metal-dependent hydrolysis of host
CC       cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC       {ECO:0000256|ARBA:ARBA00034301}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic CMP + H2O = CMP + H(+); Xref=Rhea:RHEA:72675,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58003,
CC         ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00034221};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72676;
CC         Evidence={ECO:0000256|ARBA:ARBA00034221};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865,
CC         ChEBI:CHEBI:184387; Evidence={ECO:0000256|ARBA:ARBA00034227};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576;
CC         Evidence={ECO:0000256|ARBA:ARBA00034227};
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DR   EMBL; FORT01000010; SFK23169.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I3XV65; -.
DR   STRING; 1884381.SAMN05518846_11086; -.
DR   Proteomes; UP000198915; Unassembled WGS sequence.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR43546:SF3; UPF0173 METAL-DEPENDENT HYDROLASE MJ1163; 1.
DR   PANTHER; PTHR43546; UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED; 1.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198915}.
FT   DOMAIN          7..213
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   253 AA;  27873 MW;  B2B3EE7DF8A4B0D0 CRC64;
     MHIQLVRHAT LRITYKGHTL LVDPMLSTPG ELPAVANTPN QHPNPGAALP ISVQEVLEGV
     DAIVVTHTHG DHLDPAAIQQ LPKNLPLFCQ PPDKEKLSEH GFEQVIVVQE ELEWEGIRFH
     RTGGHHGTGE IGKQMGPVSG FVLQAAEEPT LYIAGDTIWC EEVEQALATF DPNVIVVFGG
     AAQFLVGDPI TMTKEDIVQV AQTAPGSQVF VAHMEVWNHC LLSRSELREY VGENKLAERV
     QIPQNGETIE YRR
//