ID A0A1I3ZDE4_9FIRM Unreviewed; 631 AA.
AC A0A1I3ZDE4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Multidrug efflux pump subunit AcrA (Membrane-fusion protein) {ECO:0000313|EMBL:SFK42023.1};
GN ORFNames=SAMN05216390_10127 {ECO:0000313|EMBL:SFK42023.1};
OS Lachnospiraceae bacterium KH1T2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1855374 {ECO:0000313|EMBL:SFK42023.1, ECO:0000313|Proteomes:UP000198626};
RN [1] {ECO:0000313|EMBL:SFK42023.1, ECO:0000313|Proteomes:UP000198626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH1T2 {ECO:0000313|EMBL:SFK42023.1,
RC ECO:0000313|Proteomes:UP000198626};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOSY01000001; SFK42023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I3ZDE4; -.
DR STRING; 1855374.SAMN05216390_10127; -.
DR OrthoDB; 1653022at2; -.
DR Proteomes; UP000198626; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR PANTHER; PTHR32347:SF14; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198626};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 299..447
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 67380 MW; 0B50FBEDA3E1C3D7 CRC64;
MKLGIGRKKS EQNTSPSVIQ TKRKKSKKFK VILAVFLAAV IAGGGTLAYL HFNAKKVSAG
STQTFQTVTK MDISNSIAVT GTIEANESRT VSTLVSDTKV LSVSVNIGDY VEAGDPICTF
DTTSIQDKID RLLKKMDIAE QQDALEEAMA QAALNRAQED YNTNVSENAL DMTGSARSYS
DSERNVSDAE RSLSNAETDL ASAKADYEDA KDDYEDAKDD YEDLKDIYEE YYETTDSEKR
ESVLSGSGYS SIEELKEALE EAENKKDSYK STMESKEDSV TSAERAVASA ESSLSSAQSS
LESAGDSYQK SVNSAADESK SDTRTIEDKE NTLKQTELNN ATTNDENQQQ LEEYYEQLED
CYVTAPISGI ITSLSVEEGD EYNTSNSTQE ICVIQDDTSF KVTGTVDQYD IASVSENMTA
VIKTDATGDD EFDGIVTFVA PTPESSSSSG SSSSSSTEYE VEISLLDKDS RLRLGMTAET
SILTESRKGV LAVPYDCIEE DKDGNSYIYI AESGGTTEKD TKNSTSDNAA SSAGKGAEKG
KKTETTNSDG TAEITTKKVA VEKGLETDYY TEIISDEVSE GDKVLVPNSI SSSSSDSKDS
NESSMLGGMG GMSGGGGAPG GGAPGGGGGH M
//
