ID A0A1I4ATJ1_9FIRM Unreviewed; 890 AA.
AC A0A1I4ATJ1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05216390_10251 {ECO:0000313|EMBL:SFK59724.1};
OS Lachnospiraceae bacterium KH1T2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1855374 {ECO:0000313|EMBL:SFK59724.1, ECO:0000313|Proteomes:UP000198626};
RN [1] {ECO:0000313|EMBL:SFK59724.1, ECO:0000313|Proteomes:UP000198626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH1T2 {ECO:0000313|EMBL:SFK59724.1,
RC ECO:0000313|Proteomes:UP000198626};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOSY01000002; SFK59724.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4ATJ1; -.
DR STRING; 1855374.SAMN05216390_10251; -.
DR Proteomes; UP000198626; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198626}.
FT DOMAIN 703..719
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 512..539
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 629..636
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 890 AA; 100038 MW; 7BE021A872D45979 CRC64;
MTLHGKEIDR SKLSPMMLHY LETKDNYPDC ILFYRLGDFY EMFFDDAELV SKELEITLTG
KNCGLDERAP MCGVPFHAVD TYLDRLVSKG FKVAICEQLE DPKLAKGIVK RDVIRVVTPG
TNMNMQALDE GKNNFLVCIV YFADTFGVSA CDVTTGDFFV TEVPSIRQLK DELAKFMPRE
IISNEAFFMS GYDIDDMRNR LNISVSGLEE RYFTDDNAIP EIKNQFNVET LEGLGLADFE
IGCHSAGALL IYLKETQKTD LSNITHIVPY SSANYMVIDA STRRNLELTE TMREKQKRGS
LLWVLDHTRT AMGARQLRNI IEQPLIDEKE INRRLDAIEE LIERVMDRDE LREYLNAVYD
LERLLGKVTY GSANPRDLVA LKTSLAMMQP IKGVISDFKS DLLQELNNSI DGLQDIYGLI
ESSIIDDPPL AMKEGGIIKA GYNATVDELR NAQVNGKQWL AELEEREREK TGIRNLKIKF
NKVFGYAIEV TNSFLSQVPE HYIRKQTLAG GERFITDELK KMEDTILNAE EKLTALEYEI
FSDVRNTISE NISRILDTAK AVSMVDCLQS LSYTADHNGY VRPKINTKGV LNIKNGRHPV
VEQMTNSNSF VPNDCFLDQK KNLISIITGP NMAGKSTYMR QCALIVLMAS IGSFVPADSA
DICITDRIFT RVGASDDLAS GQSTFMVEMA EVANILRSAT SSSLLILDEI GRGTSTYDGL
SIAWSVVEYI ANTKVLGAKT LFATHYHELT ELEGKIPCVN NYCFSVKENG DDVVFLRKIV
KGGADKSYGI HVARLAGVPA PVIDRAGELL FELSDNDITA KVRQIETGNG KKSSRMDMVD
LNQMSFFDTV TDDDILKELS EVDLAHMTPM DALNTLYKLQ NELNNRWKNK
//
