ID A0A1I4BFQ6_9PORP Unreviewed; 1344 AA.
AC A0A1I4BFQ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN05216357_104198 {ECO:0000313|EMBL:SFK67712.1};
OS Porphyromonadaceae bacterium KH3CP3RA.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae.
OX NCBI_TaxID=1855396 {ECO:0000313|EMBL:SFK67712.1, ECO:0000313|Proteomes:UP000198708};
RN [1] {ECO:0000313|EMBL:SFK67712.1, ECO:0000313|Proteomes:UP000198708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH3CP3RA {ECO:0000313|EMBL:SFK67712.1,
RC ECO:0000313|Proteomes:UP000198708};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SIMILARITY: Belongs to the peptidase C25 family.
CC {ECO:0000256|ARBA:ARBA00006067}.
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DR EMBL; FOSU01000004; SFK67712.1; -; Genomic_DNA.
DR Proteomes; UP000198708; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17574; REC_OmpR; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR011110; Reg_prop.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR011123; Y_Y_Y.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF07494; Reg_prop; 6.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07495; Y_Y_Y; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Kinase {ECO:0000313|EMBL:SFK67712.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000313|EMBL:SFK67712.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 776..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 834..1049
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1091..1206
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1238..1337
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000259|PROSITE:PS01124"
FT MOD_RES 1139
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1344 AA; 153541 MW; EC38CE0BC5074D6E CRC64;
MQTILFIFFI FWISCLKSFS IELNFKYYKV EDGLSSNTVY AVLQDSRGFM WFGTENGLNR
FDGYTFTAYR NTPRNENSLI NNYVYCLIED GDQTLWIGTE RGVCTFDLGK DGFNPFILKT
EKGIQVSGRI QNLVPDNGKI WITSARQGVF VYENNKLSLH SFEEFKTNPD EQIWVTGIYK
DKENIIWASV DNTGHQIYRF NKESGKFTPG FPDMCFDEQK QLRAYSMLED TFGTLWFGTW
TNGLIAVDKN KGIITERHLH IPGKGKILHI HQLTEYDPGT ILIGSNDGLT SFKISPIAGN
RPDQHFREPK LSNCFVYPIY KDNEGGLWIG TYHGGINYAS PNRNYFTGYT HSRYENSITG
NVVSCFCEDP SGNIWIGTED GGLNELEVKT GKFQAYSYKD ETDGLSFDNV HALLIDNDQL
WIGTYTGGLN VMDLRTKKIK HYVSDHADKN SLDANNIYSL YRDSLENIWI GTTSGINVYN
RQSDNFTRVR NLNEIVMDIL QTGKHIWFAT INRGLQKLNL ESGKWTEYTF EYDNEHSLIS
NDVISLCIDE EQQLWIGTNH GLCRYDAEKD IFIDEKVEFQ SNYICKIFAE NGNLWIATLK
GLICYTPSTR QYRQFTKSDG LLSDLFTPNS GFKSSSGKIY LGTPNGFNTF YPKQIPKNMH
VPLIAITDFQ LFNKPVNMDG FVAENKQNQS VLTLAHNKNS FSFGFTALSF FAPEKNRYMF
MLEGFDKSWN DAGKERRATY TNIPPGNYMF RIKASNNDGV WNDEDYTLAI IIKPPLWWNG
WSITFYILFV TAGIVYLFRF LREKDRRKNE EKIAKIRSEQ EKETYRSKIE FFTNVAHEIR
TPLSLIIAPL EQIIETSDTM SDAITENLDI MRSNSQRLLT LVNQLLDFSK IEKGGIQISL
SNQNIHHLLA EIYQRFKPFI EHKHILFEYI CDDTDFETMT DAENLTKVVS NLLSNASKYT
TDHILLKLNA HLSADYYEIS VKDNGAGLSE SETEHIFKPF YQAPGQYNSG TGLGLFLVKS
IVDALDGKIA LINNPGESFS ISVVLPKINR QVEYPPPGEY STETQMSSGI EPESCDSGNI
CCDSGNDEKP SLLIVEDDKD MQAFIRKQFQ NNYLVYTAND GNEGIDILEN HPIDIIVTDM
MMPNMDGITF CKTVKQNFLW SHIPVIMLTA RTNVGSKIEA FETGADAYLD KPFHISYLSA
RIRNLLESRR LLFQKFSQTP HASLKSIAGN KTDEDFLVKL NEIIEKNIEN SDFSIDNLAK
EMGISSSGLF AKIKQISGVT PNKLILSMRL KKAAGLLSGG RYRVNEVCYR VGFNNPSYFA
KCFQKQFRKL PKDFISDPDE KTED
//
