ID   A0A1I4E0F0_9RHOB        Unreviewed;       391 AA.
AC   A0A1I4E0F0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:SFK98703.1};
GN   ORFNames=SAMN04488004_105192 {ECO:0000313|EMBL:SFK98703.1};
OS   Loktanella salsilacus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Loktanella.
OX   NCBI_TaxID=195913 {ECO:0000313|EMBL:SFK98703.1, ECO:0000313|Proteomes:UP000199550};
RN   [1] {ECO:0000313|EMBL:SFK98703.1, ECO:0000313|Proteomes:UP000199550}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16199 {ECO:0000313|EMBL:SFK98703.1,
RC   ECO:0000313|Proteomes:UP000199550};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; FOTF01000005; SFK98703.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4E0F0; -.
DR   STRING; 195913.SAMN04488004_105192; -.
DR   OrthoDB; 9764638at2; -.
DR   Proteomes; UP000199550; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199550};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SFK98703.1}.
FT   DOMAIN          4..260
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          269..390
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        88
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        347
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        377
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   391 AA;  40775 MW;  C9C2B910DAAFC365 CRC64;
     MTNVVIASAG RTAVGSFLGS FAATPAHDLG AAMLEGIVAR AGIDKSEVSE TILGQVLTAA
     QGQNPARQAH INAGLPIESS AWSLNQVCGS GLRAVAIAAQ HIQLGDASII AAGGQENMSM
     SPHAANLRQG HKMGDVSYID TMIKDGLWDA FNGYHMGQTA ENVAEKYQIS RDQQDEFAVG
     SQNKAEAAQK AGKFKDEIIP FTIKTRKGET VMDADEYIRH GATMEAMQKL RPAFAKDGSV
     TAANASGLND GAAGCLLMTA DEAEKRGIEP LARIVSYATA GLDPKIMGVG PIFASRKALE
     KAGWKAADLE LVEANEAFAA QACAVNKEMG WDPAIVNVNG GAIAIGHPIG ASGARVLNTL
     LFEMQRRGVK KGLATLCIGG GMGVAMCVER P
//