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Database: UniProt
Entry: A0A1I4GVC9_9MICO
LinkDB: A0A1I4GVC9_9MICO
Original site: A0A1I4GVC9_9MICO 
ID   A0A1I4GVC9_9MICO        Unreviewed;       631 AA.
AC   A0A1I4GVC9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   ORFNames=SAMN04515692_1035 {ECO:0000313|EMBL:SFL33297.1};
OS   Leifsonia sp. CL147.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Leifsonia.
OX   NCBI_TaxID=1798215 {ECO:0000313|EMBL:SFL33297.1, ECO:0000313|Proteomes:UP000198997};
RN   [1] {ECO:0000313|Proteomes:UP000198997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL147 {ECO:0000313|Proteomes:UP000198997};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000256|HAMAP-Rule:MF_01844}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC         Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01844};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004429}. Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC       membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the NhaA Na(+)/H(+)
CC       (TC 2.A.33) antiporter family. {ECO:0000256|ARBA:ARBA00007006}.
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DR   EMBL; FOTM01000003; SFL33297.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4GVC9; -.
DR   OrthoDB; 117402at2; -.
DR   Proteomes; UP000198997; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   Gene3D; 1.20.1530.10; Na+/H+ antiporter like domain; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   NCBIfam; TIGR00773; NhaA; 1.
DR   PANTHER; PTHR30341:SF0; NA(+)/H(+) ANTIPORTER NHAA; 1.
DR   PANTHER; PTHR30341; SODIUM ION/PROTON ANTIPORTER NHAA-RELATED; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   Pfam; PF13462; Thioredoxin_4; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|HAMAP-Rule:MF_01844};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW   Rule:MF_01844};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP-
KW   Rule:MF_01844};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01844};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198997};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|HAMAP-Rule:MF_01844};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201, ECO:0000256|HAMAP-
KW   Rule:MF_01844};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_01844};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_01844};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01844}.
FT   TRANSMEM        39..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        118..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        205..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        230..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        313..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        344..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        387..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   TRANSMEM        418..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT   DOMAIN          459..612
FT                   /note="Thioredoxin-like fold"
FT                   /evidence="ECO:0000259|Pfam:PF13462"
SQ   SEQUENCE   631 AA;  68188 MW;  E93B95D7DABB55A1 CRC64;
     MTIPLTLIQR SPDPENVGQS RDRRPTIAER FRAVGRSRLG ALLLLLATIV AIVWANISFT
     GYEQFWETHL TFGVGDLHLD FTLHALVNDA LMALFFFTVG LEVRREFAIG ELTSWSRAVV
     PVVAAVFGLA VPAVIYVLFT LGTGLEHAWG VVISTDTAFL VGALALIGPR ATGRLRVFLL
     ALAVVDDIGA LTIIALVYTQ HFTPLPLIVA ALGLVGVYFT RYLRGGRGPV YATLAIVVWL
     AFLASGVHPT LAGVAIALLI PVYRPNRIDV EHALDLARTF RQSPNTEYAR AAANSLRESI
     SINERLQSAW SPYVAYVVLP LFALANAGVR LNGDILLGAL VSPIAWGVLV GLVVGKFVGV
     FGSAALLRLL RVGEFGPGLA LDRLAGGAAL CGIGFTISLF IVDLAIPGAA MQNAARVGVL
     AATVVGFLVA TLIFRISDAR RPKEEVGTTL LRPVDPDRDH IFGSMDAPFE IVEYGDFQCG
     FCLKATGSVV EVQRELGDGL RYVWRHAPLT RFHPNALAAA EASEAASRQG KFFEFERSLF
     ADQENQLPSD IVRRARELGL DVERFEADLR SAEVAARVRD DMLDAEAMDI TAVPTFFING
     RRHSGPYDAQ SLIRDLQATA DGGRLEPSSP A
//
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