ID A0A1I4IL58_9MICO Unreviewed; 323 AA.
AC A0A1I4IL58;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN04515692_106167 {ECO:0000313|EMBL:SFL54733.1};
OS Leifsonia sp. CL147.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leifsonia.
OX NCBI_TaxID=1798215 {ECO:0000313|EMBL:SFL54733.1, ECO:0000313|Proteomes:UP000198997};
RN [1] {ECO:0000313|Proteomes:UP000198997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL147 {ECO:0000313|Proteomes:UP000198997};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOTM01000006; SFL54733.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4IL58; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000198997; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SFL54733.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198997};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 25..70
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 84..287
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 323 AA; 36245 MW; 4BB82BB9E2C72D1C CRC64;
MTRLRRSNPS GPGYHRRITD AGPVYEDEAG NRIVDDRELE RIRSLVIPPA WKDVWISPDA
RGHIQAVGTD QAGRRQYRYH DAWRLHQDRL KFDRAAQLAE TLPSARRKVT MDLREEGFGR
DRILAAAFRI IDLGSVRIGS EEYLHANGSR GLTTLLCRHA RIDGDEITLT FPAKSAQKWI
STITDADLAE LLRQIQALRG PRSRLLSWKN STWHTIRPAS LNEYIRRQTR GEFTAKDFRT
LHGTIVAAQA LAELGVAGTD GQRKKRIVAA VNEAAAALGN TPAIARNSYI DPRVFDRYRN
GEVIDISGGR APEPALLELL STS
//
