ID   A0A1I4JRI4_9BACI        Unreviewed;      1048 AA.
AC   A0A1I4JRI4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:SFL69152.1};
GN   ORFNames=SAMN04487943_103119 {ECO:0000313|EMBL:SFL69152.1};
OS   Gracilibacillus orientalis.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Gracilibacillus.
OX   NCBI_TaxID=334253 {ECO:0000313|EMBL:SFL69152.1, ECO:0000313|Proteomes:UP000198565};
RN   [1] {ECO:0000313|EMBL:SFL69152.1, ECO:0000313|Proteomes:UP000198565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.4250 {ECO:0000313|EMBL:SFL69152.1,
RC   ECO:0000313|Proteomes:UP000198565};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FOTR01000003; SFL69152.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4JRI4; -.
DR   STRING; 334253.SAMN04487943_103119; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000198565; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          512..590
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1048 AA;  120916 MW;  8EA2B66246136C42 CRC64;
     MKRIHRLIRL LRNNQYIATK TINNWEMNLF KYEGPENYQP LEQENSPETA DIGGPLIESG
     VTAFLNNHIE IPNDWSSKDI GIIFKAGGPG GISSHYEALM NINGEPIQGF DRNRSFCFLA
     EHILDRSILN IEIELFNPVG IPEDSLRGFN QVASAETAPP SIFLEDSALV LVNRAVESFV
     YTLQTACNTL ALIPESDTRY SILYKRLEDL ANEWKIPDKK NLMNQKELLK QEQSIQSLLK
     EISGYREGTI RAIGQSHIDV AWLWPLKETI RKASRTFSTA CTLLDEYEEF EYAQSQPQLF
     EYLKNYYPKI YERVKQQIKA GRFEIIGGMW VEPDLNIPSG ESLVRQLLYG KQYFKEEFGE
     EPKVEWLPDT FGYCASLPQI LKKADTEYFM TTKLNWNDTN RFPYDLFHWE GIDGTTILSY
     LHTILGQQTN PKDIKETWND FNQKNDHNER MLVYGYGDGG GGVTREMIEQ VKRSKSLPGL
     PNVKFSKVHD FFGHISQQKP ALPKWYGDLY LELHRGTYTT HAKTKKYNRQ VESLLRNVEI
     WHSFVHLLIG TDYPAQRIKK LWKLILLNQF HDIVPGTSIE PVYELSDQQY QEVMSEGESL
     QREAIEQIKS RVDTNGPGEP LIIFNSLGWD RDRLIKVNGD QDLLSKTIVD EEGNPYPKEY
     VRVDNSTIEL HAFISNVPQF GYKTVWVQEE EGNILASSQS LNGKWETVNY IVEFTEQGFI
     SRLYDKQCDK EIIQSGEVAN ELQLFDDLPT DWDAWDIDPN FASQKIDNMK LLEETVHYTS
     NLTDELHFKW KLNESIITQK IIFHHYSKLI DFETEVDWKE TNKLLKVAFP VNVYSSQATY
     EIPFGTIDRP THNNTTWEQA QYEVCGQRWA DLSEGTYGVS LLNDSKYGYD IKGQNIRLSL
     LRSPKWPDQS ADTHRHQFVY SLYPHQGDWK AADTVKKGHE LNTRDLISPA KTSQGNLLNS
     SSFIRIESES AILDAVKLAE NEKGLIVRLY EAEGSEVSTT VTLPEKVVFQ ETNLLEKTID
     HSLVSTDSYK MKLKPYEICT YQIRSEKG
//